Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.61 |
| ▸ | HTR1A | P08908 | 10/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11635336 | 0.98 | HTR7 (0.58) | HTR7HTR1AL3MBTL1KDM4ELMNA | |
| SCHEMBL11631804 | 0.94 | L3MBTL1 (0.59) | HTR7HTR1AL3MBTL1KDM4ELMNA | |
| SCHEMBL11629816 | 0.86 | HTR7 (0.67) | HTR7HTR1AL3MBTL1KDM4EDRD2 | |
| SCHEMBL11630691 | 0.84 | KDM4E (0.61) | HTR7HTR1AL3MBTL1KDM4ELMNA | |
| SCHEMBL11744576 | 0.84 | L3MBTL1 (0.53) | HTR7HTR1AL3MBTL1KDM4EDRD2 | |
| SCHEMBL11629224 | 0.84 | DRD2 (0.56) | HTR7HTR1AL3MBTL1KDM4ELMNA | |
| SCHEMBL11632747 | 0.84 | L3MBTL1 (0.47) | HTR7L3MBTL1 | |
| SCHEMBL11632263 | 0.84 | HTR7 (0.64) | HTR7HTR1AL3MBTL1KDM4EDRD2 | |
| SCHEMBL11629868 | 0.83 | SIGMAR1 (0.47) | HTR7L3MBTL1 | |
| SCHEMBL11631445 | 0.83 | SIGMAR1 (0.47) | HTR7L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |