Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11631389 | 0.86 | L3MBTL1 (0.55) | DRD2L3MBTL1HTR1A | |
| SCHEMBL11632940 | 0.86 | L3MBTL1 (0.47) | DRD2L3MBTL1DRD4MCHR1 | |
| SCHEMBL11635491 | 0.84 | HTR7 (0.59) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL11631902 | 0.84 | L3MBTL1 (0.49) | DRD2L3MBTL1HTR1AHTR2AHTR7 | |
| SCHEMBL11633185 | 0.83 | L3MBTL1 (0.47) | DRD2L3MBTL1DRD4HTR1AHTR2A | |
| SCHEMBL11630316 | 0.82 | OPRM1 (0.52) | DRD2L3MBTL1DRD4CHRM4TRPV6 | |
| SCHEMBL11631327 | 0.82 | L3MBTL1 (0.49) | DRD2L3MBTL1HTR1AHTR2AHTR7 | |
| SCHEMBL11633522 | 0.81 | L3MBTL1 (0.47) | DRD2L3MBTL1DRD4HTR7CHRM4 | |
| SCHEMBL11632747 | 0.81 | L3MBTL1 (0.47) | L3MBTL1HTR7 | |
| SCHEMBL11813026 | 0.80 | DRD2 (0.58) | DRD2GRM2DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |