Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11634992 | 0.87 | L3MBTL1 (0.53) | OPRL1TP53SIGMAR1KDM4EL3MBTL1 | |
| SCHEMBL11629858 | 0.85 | L3MBTL1 (0.44) | OPRM1OPRL1SIGMAR1KDM4EL3MBTL1 | |
| SCHEMBL11633475 | 0.84 | L3MBTL1 (0.45) | OPRM1OPRL1OPRD1OPRK1KDM4E | |
| SCHEMBL11635491 | 0.83 | HTR7 (0.59) | OPRM1ABCB11SIGMAR1DRD2DRD3 | |
| SCHEMBL11634977 | 0.82 | L3MBTL1 (0.47) | OPRM1OPRL1KDM4EL3MBTL1DRD2 | |
| SCHEMBL11635382 | 0.82 | DRD2 (0.53) | L3MBTL1DRD4DRD2CHRM4TRPV6 | |
| SCHEMBL11629536 | 0.81 | SIGMAR1 (0.46) | OPRL1SIGMAR1L3MBTL1DRD2LMNA | |
| SCHEMBL11629977 | 0.81 | SIGMAR1 (0.46) | OPRL1SIGMAR1L3MBTL1DRD2LMNA | |
| SCHEMBL11630996 | 0.81 | SIGMAR1 (0.46) | OPRL1SIGMAR1L3MBTL1DRD2LMNA | |
| SCHEMBL11811302 | 0.81 | MAPK1 (0.56) | OPRM1OPRL1OPRD1OPRK1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |