Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874796 | 0.85 | HRH3 (0.45) | HTR2ATAAR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1163325 | 0.83 | HTR6 (0.52) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL1163366 | 0.82 | HTR2A (0.43) | HTR2AHTR1AHTR6HTR1D | |
| SCHEMBL3176741 | 0.79 | HTR2A (0.60) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL1163260 | 0.78 | HTR2A (0.43) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL3173096 | 0.77 | HTR2A (0.53) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL3182797 | 0.77 | HTR2A (0.64) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL1163178 | 0.75 | HTR6 (0.54) | HTR2AHTR2CHTR1AHTR2BHTR6 | |
| SCHEMBL3176986 | 0.75 | HTR2A (0.63) | HTR2AHTR2CHTR1AHTR2BTAAR1 | |
| SCHEMBL3177851 | 0.75 | HTR1A (0.47) | HTR2AHTR2CHTR1AHTR2BTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464227-A1 | COMPOUNDS AND METHODS OF USE THEREOF | Galenea Corporation (US) | 2012-06-20 | — | — | EP | claimed |
| US-20110143977-A1 | Lubricating Compositions Containing Sulphonates and Phenates | THE LUBRIZOL CORPORATION | 2011-06-16 | — | — | US | claimed |
| US-20110144090-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION | 2011-06-16 | — | — | US | claimed |
| WO-2011019738-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2011-02-17 | — | — | WO | claimed |
| US-7678746-B2 | Mixing an overbased polysulfonate detergent, oligomers or polyphenylene thioethers of a 2,6-dimercaptophenol, and other performance additives; adding to an API Group I, Group II, Group III, or Group IV oil; marine diesel engines with improved cleanliness, decreased cylinder wear and deposits | THE LUBRIZOL CORPORATION (US) | 2010-03-16 | — | — | US | claimed |
| EP-1753849-A2 | LUBRICATING COMPOSITIONS CONTAINING SULPHONATES AND PHENATES | The Lubrizol Corporation (US) | 2007-02-21 | — | — | EP | claimed |
| WO-2005112575-A2 | LUBRICATING COMPOSITIONS CONTAINING SULPHONATES AND PHENATES | THE LUBRIZOL CORPORATION (US) | 2005-12-01 | — | — | WO | claimed |
| US-20050209110-A1 | Mixing an overbased polysulfonate detergent, oligomers or polyphenylene thioethers of a 2,6-dimercaptophenol, and other performance additives; adding to an API Group I, Group II, Group III, or Group IV oil; marine diesel engines with improved cleanliness, decreased cylinder wear and deposits | THE LUBRIZOL CORPORATION (US) | 2005-09-22 | — | — | US | claimed |
| US-20170342054-A1 | COMPOUNDS AND METHODS OF USE THEREOF | ELDER AMY (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170342054-A1 | COMPOUNDS AND METHODS OF USE THEREOF | ELDER AMY (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170342054-A1 | COMPOUNDS AND METHODS OF USE THEREOF | ELDER AMY (US) | 2017-11-30 | — | — | US | disclosed |
| US-20150284365-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150284365-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150284365-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2015-10-08 | — | — | US | disclosed |
| US-20110143977-A1 | Lubricating Compositions Containing Sulphonates and Phenates | THE LUBRIZOL CORPORATION | 2011-06-16 | — | — | US | disclosed |
| WO-2011019738-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2011-02-17 | — | — | WO | disclosed |
| US-7678746-B2 | Mixing an overbased polysulfonate detergent, oligomers or polyphenylene thioethers of a 2,6-dimercaptophenol, and other performance additives; adding to an API Group I, Group II, Group III, or Group IV oil; marine diesel engines with improved cleanliness, decreased cylinder wear and deposits | THE LUBRIZOL CORPORATION (US) | 2010-03-16 | — | — | US | disclosed |
| EP-1753849-A2 | LUBRICATING COMPOSITIONS CONTAINING SULPHONATES AND PHENATES | The Lubrizol Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005112575-A2 | LUBRICATING COMPOSITIONS CONTAINING SULPHONATES AND PHENATES | THE LUBRIZOL CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050209110-A1 | Mixing an overbased polysulfonate detergent, oligomers or polyphenylene thioethers of a 2,6-dimercaptophenol, and other performance additives; adding to an API Group I, Group II, Group III, or Group IV oil; marine diesel engines with improved cleanliness, decreased cylinder wear and deposits | THE LUBRIZOL CORPORATION (US) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342054-A1 | COMPOUNDS AND METHODS OF USE THEREOF | AANAT, HNMT, INMT | HTR2A 34/4885HTR2C 27/4885HTR1A 38/4885 |
| US-20150284365-A1 | COMPOUNDS AND METHODS OF USE THEREOF | AANAT, HNMT, INMT | HTR2A 34/4885HTR2C 27/4885HTR1A 38/4885 |
| US-20110144090-A1 | COMPOUNDS AND METHODS OF USE THEREOF | AANAT, HNMT, INMT | HTR2A 34/4885HTR2C 27/4885HTR1A 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.