Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.63 |
| ▸ | HTR2C | P28335 | 9/20 | 0.63 |
| ▸ | HTR2B | P41595 | 6/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | ICMT | O60725 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | DNM2 | P50570 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173096 | 0.93 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR1AICMT | |
| SCHEMBL3182797 | 0.88 | HTR2A (0.64) | HTR2AHTR2CHTR2BHTR1ATAAR1 | |
| SCHEMBL3176741 | 0.87 | HTR2A (0.60) | HTR2AHTR2CHTR2BHTR1ATAAR1 | |
| SCHEMBL1163754 | 0.82 | HTR2C (0.58) | HTR2AHTR2CHTR2BHTR1ATAAR1 | |
| SCHEMBL3177851 | 0.81 | HTR1A (0.47) | HTR2AHTR2CHTR2BHTR1ATAAR1 | |
| SCHEMBL3184470 | 0.80 | HTR2A (0.64) | HTR2AHTR2CHTR2BHTR1AICMT | |
| SCHEMBL1163325 | 0.80 | HTR6 (0.52) | HTR2AHTR2CHTR2BHTR1ATAAR1 | |
| SCHEMBL23805226 | 0.78 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1AICMT | |
| SCHEMBL3183284 | 0.77 | HTR2A (0.46) | HTR2AHTR2CHTR2BICMTTAAR1 | |
| SCHEMBL3172608 | 0.76 | HTR1A (0.50) | HTR2AHTR2CHTR2BHTR1ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655691-B2 | Indole compounds useful as serotonin selective agents | ORGANIX, INC. | 2010-02-02 | — | — | US | claimed |
| US-8071786-B2 | Indole compounds useful as serotonin selective agents | GALENEA CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100137616-A1 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | SARD HOWARD P | 2010-06-03 | — | — | US | disclosed |
| US-7655691-B2 | Indole compounds useful as serotonin selective agents | ORGANIX, INC. | 2010-02-02 | — | — | US | disclosed |
| EP-1799640-A4 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | ORGANIX INC (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1799640-A2 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | Organix, Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060100266-A1 | Indole compounds useful as serotonin selective agents | ORGANIX, INC. (US) | 2006-05-11 | — | — | US | disclosed |
| WO-2006047032-A2 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | ORGANIX, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137616-A1 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | TPH1, TPH2, AANAT | HTR2A 11/4885HTR2C 15/4885HTR2B 16/4885 |
| US-20060100266-A1 | Indole compounds useful as serotonin selective agents | TPH1, TPH2, AANAT | HTR2A 11/4885HTR2C 15/4885HTR2B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.