Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637308 | 0.76 | MEN1 (0.38) | ALDH1A1ALOX12HTTPKMPOLB | |
| SCHEMBL9541322 | 0.73 | KEAP1 (0.39) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL3882288 | 0.73 | PSIP1 (0.50) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL7194392 | 0.73 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL4250262 | 0.73 | PLCG1 (0.56) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL1911882 | 0.71 | TSHR (0.58) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL11692985 | 0.70 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL9703985 | 0.70 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL385916 | 0.70 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL8765877 | 0.70 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1ALOX12HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4098823-A | VASODILATION, HYPOTENSIVE AGENTS, ANTICOAGULATNS, ANTISECRETORY AGENTS, INOTROPIC AGENTS | MILES LABORATORIES, INC. (US) | 1978-07-04 | — | — | US | disclosed |