SCHEMBL11645697

SCHEMBL11645697

CN1CCNCC1(C)Cc1ccc2c(c1)OCO2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.40
SLC6A4 P31645 2/20 0.40
ALDH1A1 P00352 2/20 0.40
GAA P10253 2/20 0.40
HSD17B10 Q99714 2/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A3 Q01959 1/20 0.40
CMA1 P23946 1/20 0.40
DPP7 Q9UHL4 1/20 0.40
MIF P14174 1/20 0.40
CYP3A4 P08684 2/20 0.39
PIM1 P11309 1/20 0.39
DYRK2 Q92630 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTT P42858 1/20 0.39
CYP1A2 P05177 1/20 0.39
MAPT P10636 1/20 0.39
KDM4E B2RXH2 2/20 0.39
GLA P06280 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11643819 0.92 CYP2D6 (0.41) ALDH1A1GAACYP2D6HTTMAPT
SCHEMBL11626985 0.76 CA2 (0.41) ALDH1A1HSD17B10CYP2D6HTTKDM4E
SCHEMBL11643025 0.76 TAAR1 (0.42) TAAR1SLC6A4SLC6A2SLC6A3CMA1
SCHEMBL11644193 0.75 CYP2D6 (0.52) ALDH1A1GAACYP2D6HTTMAPK1
SCHEMBL11630403 0.74 MAPT (0.39) ALDH1A1GAAHSD17B10CYP2C19HTT
SCHEMBL11644296 0.74 ALDH1A1 (0.47) ALDH1A1GAAHSD17B10CMA1DPP7
SCHEMBL11642604 0.72 OPRD1 (0.47) ALDH1A1HSD17B10SLC6A3CYP2D6MAPT
SCHEMBL17967831 0.71 TAAR1 (0.46) TAAR1SLC6A4ALDH1A1GAASLC6A2
Hydrochloric Acid SCHEMBL11647354 0.71 MEN1 (0.48) ALDH1A1GAAHSD17B10HTTMAPT
SCHEMBL3784351 0.71 SIGMAR1 (0.57) TAAR1SLC6A4SLC6A2SLC6A3DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4088763-A VASCULAR AND CARDIAC DISEASES KNOLL A.G. CHEMISCHE FABRIKEN (DT) 1978-05-09 US claimed
US-4088763-A VASCULAR AND CARDIAC DISEASES KNOLL A.G. CHEMISCHE FABRIKEN (DT) 1978-05-09 US disclosed