SCHEMBL11697995

SCHEMBL11697995

O=C1Oc2ccccc2CCC1Br

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.41
MAOB P27338 2/20 0.41
CA2 P00918 2/20 0.37
ANPEP P15144 3/20 0.36
GAA P10253 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
NOTUM Q6P988 1/20 0.33
KLK5 Q9Y337 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
MEN1 O00255 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3345089 0.81 MAOB (0.43) MAOAMAOBGAANPSR1KLK5
SCHEMBL14169945 0.75 PDPK1 (0.53) MAOAMAOBCA2ADRA2AADRA2B
SCHEMBL28078245 0.69 CA2 (0.44) MAOAMAOBCA2HTR1AADRA2A
SCHEMBL30360775 0.69 MAOA (0.70) MAOAMAOBGAANPSR1
SCHEMBL971330 0.69 MAOA (0.70) MAOAMAOBGAANPSR1
Dihydrocoumarin SCHEMBL17629427 0.69 MAOB (0.50) MAOAMAOBGAANPSR1CYP2C9
Dihydrocoumarin SCHEMBL28795 0.69 MAOB (0.50) MAOAMAOBGAANPSR1CYP2C9
Dihydrocoumarin SCHEMBL29350292 0.69 MAOB (0.50) MAOAMAOBGAANPSR1CYP2C9
SCHEMBL3346153 0.68 CYP19A1 (0.51) MAOAMAOBHTR1ASIGMAR1
SCHEMBL29604926 0.68 CYP19A1 (0.51) MAOAMAOBHTR1ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4032686-A ARTICLES COATED WITH A CURED COMPOSITION OF HYDROXY(POLYALKYLENECARBONYLOXY)ALKYLENEOXAZOLIDINE AND A POLYISOCYANATE ROHM AND HAAS COMPANY (US) 1977-06-28 US disclosed
US-4024117-A HYDROXY-ALKYLENE-OXAZOLIDINE, ISOCYANATE ROHM AND HAAS COMPANY (US) 1977-05-17 US disclosed