Guabenxan

Guabenxan

SCHEMBL1172002

N=C(N)NCc1ccc2c(c1)OCCO2

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
GAA P10253 3/20 0.54
ALOX12 P18054 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.49
HPGD P15428 3/20 0.48
RAB9A P51151 3/20 0.47
HSD17B10 Q99714 2/20 0.47
LMNA P02545 2/20 0.47
MEN1 O00255 1/20 0.47
MAPK1 P28482 1/20 0.47
MMP13 P45452 1/20 0.47
KMT2A Q03164 1/20 0.47
RECQL P46063 2/20 0.46
TP53 P04637 1/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
NPC1 O15118 1/20 0.46
KDM4E B2RXH2 1/20 0.45
KDM1A O60341 1/20 0.45
MAOA P21397 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4015808 0.90 GAA (0.67) ALDH1A1GAAALOX12SMN1; SMN2HPGD
SCHEMBL30496722 0.90 GAA (0.67) ALDH1A1GAAALOX12SMN1; SMN2HPGD
Hydrochloric Acid SCHEMBL28129391 0.89 GAA (0.65) ALDH1A1GAAALOX12SMN1; SMN2HPGD
SCHEMBL14868335 0.79 ALDH1A1 (0.60) ALDH1A1GAAALOX12SMN1; SMN2HPGD
SCHEMBL30226354 0.79 ALDH1A1 (0.60) ALDH1A1GAAALOX12SMN1; SMN2HPGD
SCHEMBL2937839 0.79 ALDH1A1 (0.65) ALDH1A1GAASMN1; SMN2HPGDRAB9A
Hydrochloric Acid SCHEMBL19371392 0.78 GAA (0.58) ALDH1A1GAAALOX12SMN1; SMN2HPGD
SCHEMBL17468447 0.77 ALDH1A1 (0.63) ALDH1A1GAASMN1; SMN2HPGDRAB9A
SCHEMBL17198920 0.77 LMNA (0.52) ALDH1A1GAASMN1; SMN2RAB9ALMNA
SCHEMBL17198858 0.75 TAAR1 (0.57) ALDH1A1GAAALOX12SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-6946141-B2 As-needed administration of tricyclic and other non-SRI antidepressant drugs to treat premature ejaculation VIVUS, INC. (US) 2005-09-20 US claimed
EP-1389115-A2 AS-NEEDED ADMINISTRATION OF TRICYCLIC AND OTHER NON-SRI ANTIDEPRESSANT DRUGS TO TREAT PREMATURE EJACULATION Vivus, Inc. (US) 2004-02-18 EP claimed
US-6495154-B1 ADMINISTERING ANTIDEPRESSANTS, ADRENERGIC STIMULANTS, SEROTONIN AGONISTS AND ANTAGONISTS AS THERAPEUTIC AGENTS FOR SEXUAL DISORDERS VIVUS INC. 2002-12-17 US claimed
US-20020161016-A1 As-needed administration of tricyclic and other non-SRI antidepressant drugs to treat premature ejaculation VIVUS LLC (F/K/A VIVUS, INC.) 2002-10-31 US claimed
WO-2002041883-A2 AS-NEEDED ADMINISTRATION OF TRICYCLIC AND OTHER NON-SRI ANTIDEPRESSANT DRUGS TO TREAT PREMATURE EJACULATION VIVUS, INC. (US) 2002-05-30 WO claimed
US-20010008896-A1 Administration of active agents, including 5-HT receptor agonists and antagonists, to treat premature ejaculation SMITH WILLIAM L (US) 2001-07-19 US claimed
US-5922341-A Local administration of pharmacologically active agents to treat premature ejaculation VIVUS, INCORPORATED (US) 1999-07-13 US claimed
US-20260077139-A1 SPACER DEVICE WITH FLOW RATE SPIROMETER AEROVU TECHNOLOGIES, INC. (US) 2026-03-19 US disclosed
US-12514993-B2 Spacer device with flow rate spirometer AEROVU TECHNOLOGIES, INC. (US) 2026-01-06 US disclosed
US-20250339374-A1 BONDED MICROPARTICULATES PREPARATION AND APPLICATIONS THEREOF VENKOR CORP (US) 2025-11-06 US disclosed
US-6228864-B1 Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation VIVUS, INC. 2001-05-08 US disclosed
EP-1027011-A1 ADMINISTRATION OF ACTIVE AGENTS, INCLUDING 5-HT RECEPTOR AGONISTS AND ANTAGONISTS, TO TREAT PREMATURE EJACULATION Vivus, Inc. (US) 2000-08-16 EP disclosed
US-5922341-A Local administration of pharmacologically active agents to treat premature ejaculation VIVUS, INCORPORATED (US) 1999-07-13 US disclosed
WO-1999021508-A1 ADMINISTRATION OF ACTIVE AGENTS, INCLUDING 5-HT RECEPTOR AGONISTS AND ANTAGONISTS, TO TREAT PREMATURE EJACULATION VIVUS, INC. (US) 1999-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020161016-A1 As-needed administration of tricyclic and other non-SRI antidepressant drugs to treat premature ejaculation HTR5A, HTR1A, MAOA ALDH1A1 869/4885GAA 497/4885ALOX12 2534/4885
US-20260077139-A1 SPACER DEVICE WITH FLOW RATE SPIROMETER TMCO1, CFTR, CYSLTR2 ALDH1A1 4087/4885GAA 4774/4885ALOX12 1562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.