Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | RPS27 | P42677 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143956 | 0.98 | SMN1; SMN2 (0.35) | SMN1; SMN2CCNA2CDK2TTKRPS27 | |
| Hydrochloric Acid SCHEMBL11743005 | 0.97 | SMN1; SMN2 (0.34) | SMN1; SMN2CCNA2CDK2TTKRPS27 | |
| SCHEMBL11738008 | 0.93 | GLP1R (0.37) | SMN1; SMN2CCNA2CDK2TTKRPS27 | |
| SCHEMBL11733104 | 0.84 | POLB (0.42) | SMN1; SMN2CCNA2CDK2TTKRPS27 | |
| SCHEMBL11740878 | 0.83 | CYP3A4 (0.41) | CCNA2CDK2TTKRPS27MAPK8 | |
| SCHEMBL11744059 | 0.81 | SLC29A1 (0.34) | SMN1; SMN2CDK2KDM4ELMNAHPGD | |
| SCHEMBL11738829 | 0.80 | ALDH1A1 (0.40) | CDK2MAPTALDH1A1 | |
| SCHEMBL11737201 | 0.79 | NPSR1 (0.33) | SMN1; SMN2MAPK8KDM4ELMNAHPGD | |
| SCHEMBL17393535 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL11716065 | 0.71 | GLP1R (0.35) | CDK2GLP1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4052510-A | 4-ALKYL-2,6-DI(SECONDARY OR TERTIARY ALKYLAMINO) PYRIDINES, COMPOSITIONS THEREOF AND METHODS FOR TREATING DIABETES AND OBESITY | SANDOZ, INC. (US) | 1977-10-04 | — | — | US | disclosed |