Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | RPS27 | P42677 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143956 | 0.94 | SMN1; SMN2 (0.35) | GLP1RSMN1; SMN2CCNA2CDK2TTK | |
| Bromide SCHEMBL11739645 | 0.93 | SMN1; SMN2 (0.34) | GLP1RSMN1; SMN2CCNA2CDK2TTK | |
| Hydrochloric Acid SCHEMBL11743005 | 0.93 | SMN1; SMN2 (0.34) | GLP1RSMN1; SMN2CCNA2CDK2TTK | |
| SCHEMBL11733104 | 0.81 | POLB (0.42) | SMN1; SMN2CCNA2CDK2TTKRPS27 | |
| SCHEMBL11744059 | 0.77 | SLC29A1 (0.34) | SMN1; SMN2L3MBTL1CDK2ALDH1A1 | |
| SCHEMBL11738829 | 0.76 | ALDH1A1 (0.40) | CDK2ALDH1A1 | |
| SCHEMBL11737201 | 0.75 | NPSR1 (0.33) | SMN1; SMN2MAPK8ALDH1A1 | |
| SCHEMBL11716065 | 0.71 | GLP1R (0.35) | GLP1RCDK2 | |
| SCHEMBL17393535 | 0.70 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL11738920 | 0.67 | MEN1 (0.34) | CCNA2CDK2TTKRPS27MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4052510-A | 4-ALKYL-2,6-DI(SECONDARY OR TERTIARY ALKYLAMINO) PYRIDINES, COMPOSITIONS THEREOF AND METHODS FOR TREATING DIABETES AND OBESITY | SANDOZ, INC. (US) | 1977-10-04 | — | — | US | disclosed |