Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29384281 | 0.75 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL473877 | 0.75 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL5143956 | 0.74 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL28528625 | 0.73 | SORT1 (0.46) | SMN1; SMN2ALDH1A1MAPK1KDM4ESORT1 | |
| SCHEMBL3340047 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPK1POLBKDM4E | |
| SCHEMBL29898229 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPK1POLBKDM4E | |
| Hydrochloric Acid SCHEMBL11743005 | 0.73 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| Bromide SCHEMBL11739645 | 0.73 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL11733104 | 0.73 | POLB (0.42) | SMN1; SMN2ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL11740878 | 0.72 | CYP3A4 (0.41) | ALDH1A1POLBKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655889-B2 | Inhibitors of human immunodeficiency virus replication | VIIV Healthcare UK (No.5) Limited (GB) | 2017-05-23 | — | — | US | disclosed |
| US-20160000771-A1 | Inhibitors of Human Immunodeficiency Virus Replication | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000771-A1 | Inhibitors of Human Immunodeficiency Virus Replication | EIF2AK2, RTF2, MAVS | SMN1; SMN2 3068/4885ALDH1A1 3508/4885MAPK1 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.