Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 7/20 | 0.42 |
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CFD | P00746 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11744394 | 1.00 | PTGS1 (0.42) | PTGS1PTGS2PLCG1PHLPP2CA1 | |
| SCHEMBL11743616 | 0.88 | PTGS1 (0.42) | PTGS1PTGS2PHLPP2CA1CA2 | |
| SCHEMBL11744400 | 0.88 | PHLPP2 (0.49) | PTGS1PTGS2PHLPP2CA1CA2 | |
| SCHEMBL11743625 | 0.88 | PTGS1 (0.42) | PTGS1PTGS2PHLPP2CA1CA2 | |
| SCHEMBL28052984 | 0.83 | MAPT (0.49) | PTGS1PTGS2PHLPP2CA1CA2 | |
| Potassium Ion SCHEMBL11747949 | 0.82 | PTGS2 (0.56) | PTGS1PTGS2PLCG1PHLPP2CA1 | |
| Potassium Ion SCHEMBL11747963 | 0.82 | PTGS2 (0.56) | PTGS1PTGS2PLCG1PHLPP2CA1 | |
| Potassium Ion SCHEMBL8069274 | 0.81 | PTGS2 (0.48) | PTGS2CA2ALDH1A1KDM4EMAPT | |
| SCHEMBL11743145 | 0.78 | MEN1 (0.62) | CA1CA2ALDH1A1CYP2C9KDM4E | |
| SCHEMBL11743138 | 0.78 | MEN1 (0.62) | CA1CA2ALDH1A1CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4045429-A | 4-(4-Hydroxy- or acetoxy-3-carbomethoxyphenylazo)-benzenesulphonyl chloride | PHARMACIA AKTIEBOLAG (SW) | 1977-08-30 | — | — | US | disclosed |