Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSH | P09668 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176985 | 1.00 | LTA4H (0.46) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL390537 | 1.00 | LTA4H (0.46) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL564014 | 0.91 | KMT2A (0.39) | LTA4HMMP2MMP9MMP12MMP1 | |
| SCHEMBL27792200 | 0.84 | LTA4H (0.47) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL14686379 | 0.82 | MMP2 (0.44) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL4244240 | 0.81 | ALDH1A1 (0.41) | LTA4HCTSKCTSDTSHRALDH1A1 | |
| SCHEMBL2856572 | 0.80 | MMP2 (0.50) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL9208253 | 0.80 | MMP2 (0.50) | LTA4HMMP2MMP9MMP12LMNA | |
| SCHEMBL389670 | 0.80 | ALDH1A1 (0.40) | LTA4HCTSKTSHRALDH1A1KMT2A | |
| SCHEMBL389669 | 0.80 | ALDH1A1 (0.40) | LTA4HCTSKTSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394823-B2 | Triazolopyridine compounds useful as DGAT1 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-12 | — | — | US | disclosed |
| EP-1975170-B9 | Bisphosphine ligands for asymmetric syntheses | DAIICHI FINE CHEM CO LTD (JP) | 2011-11-02 | — | — | EP | disclosed |
| EP-1975170-B9 | Bisphosphine ligands for asymmetric syntheses | DAIICHI FINE CHEM CO LTD (JP) | 2011-11-02 | — | — | EP | disclosed |
| EP-2376427-A1 | CRYSTALLINE FORMS OF A 3-CARBOXYPROPYL-AMINOTETRALIN COMPOUND | Theravance, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7935841-B2 | Bisphospholanes for use as catalysts in asymmetric reactions | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-05-03 | — | — | US | disclosed |
| US-7935841-B2 | Bisphospholanes for use as catalysts in asymmetric reactions | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-05-03 | — | — | US | disclosed |
| US-7935841-B2 | Bisphospholanes for use as catalysts in asymmetric reactions | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-05-03 | — | — | US | disclosed |
| EP-1975170-B1 | Bisphosphine ligands for asymmetric syntheses | DAIICHI FINE CHEM CO LTD (JP) | 2011-03-09 | — | — | EP | disclosed |
| EP-1975170-B1 | Bisphosphine ligands for asymmetric syntheses | DAIICHI FINE CHEM CO LTD (JP) | 2011-03-09 | — | — | EP | disclosed |
| US-20110034506-A1 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS DGAT1 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-10 | — | — | US | disclosed |
| US-20040127549-A1 | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
| US-20040106805-A1 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2004-06-03 | — | — | US | disclosed |
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| EP-1358174-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057248-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127549-A1 | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | LTA4H 1757/4885MMP2 112/4885MMP9 604/4885 |
| US-20040106805-A1 | Inhibitors of cruzipain and other cysteine proteases | CTRL, CPN1, CPA1 | LTA4H 1318/4885MMP2 85/4885MMP9 219/4885 |
| US-20110034506-A1 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS DGAT1 INHIBITORS | DGAT1, DGAT2, SOAT1 | LTA4H 3291/4885MMP2 2358/4885MMP9 2814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.