Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 8/20 | 0.57 |
| ▸ | TTR | P02766 | 3/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802620 | 0.98 | GPR35 (0.59) | GPR35TTRVCAM1ABCC3ABCC4 | |
| Potassium SCHEMBL11799629 | 0.97 | GPR35 (0.57) | GPR35TTRVCAM1ABCC3ABCC4 | |
| SCHEMBL11799616 | 0.97 | GPR35 (0.57) | GPR35TTRVCAM1ABCC3ABCC4 | |
| SCHEMBL11799631 | 0.86 | GPR35 (0.61) | GPR35TTRABCC3ABCC4NR1I2 | |
| SCHEMBL12727246 | 0.83 | GPR35 (0.57) | GPR35TTRVCAM1ABCC3ABCC4 | |
| SCHEMBL3770749 | 0.83 | TTR (0.62) | GPR35TTRVCAM1ALDH1A1LMNA | |
| SCHEMBL11150662 | 0.83 | VCAM1 (0.50) | GPR35VCAM1MAPTALDH1A1LMNA | |
| SCHEMBL4901895 | 0.83 | GPR35 (0.61) | GPR35TTRVCAM1ABCC3ABCC4 | |
| SCHEMBL6036460 | 0.81 | TTR (0.62) | GPR35TTRABCC3ABCC4NR1I2 | |
| SCHEMBL11817166 | 0.81 | GPR35 (0.54) | GPR35TTRVCAM1ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3933472-A | Substituted alkylaryl ketones and methods of use as herbicides | BUCKMAN LABORATORIES, INC. (US) | 1976-01-20 | — | — | US | disclosed |