Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811379 | 0.85 | KMT2A (0.47) | ALDH1A1CHEK1SIGMAR1TRPA1AMPD2 | |
| SCHEMBL8204263 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CHEK1SIGMAR1LMNACXCR3 | |
| SCHEMBL11119636 | 0.83 | CHEK1 (0.44) | ALDH1A1CHEK1POLBNPSR1 | |
| SCHEMBL16365587 | 0.83 | CHEK1 (0.41) | CHEK1LMNA | |
| SCHEMBL11814837 | 0.82 | GAA (0.44) | CHEK1SIGMAR1AMPD2POLBLMNA | |
| SCHEMBL11811596 | 0.81 | SIGMAR1 (0.50) | KDM4EALDH1A1CHEK1SIGMAR1AMPD2 | |
| SCHEMBL11813133 | 0.80 | SIGMAR1 (0.47) | KDM4EALDH1A1SIGMAR1MAPTSMN1; SMN2 | |
| SCHEMBL12157029 | 0.79 | CHEK1 (0.39) | ALDH1A1CHEK1POLBMAPTLMNA | |
| SCHEMBL16367847 | 0.79 | LPL (0.44) | CHEK1 | |
| SCHEMBL3144024 | 0.78 | AMPD2 (0.40) | KDM4EALDH1A1SIGMAR1AMPD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975357-A | SUBSTITUTED PIPERIDINES | SANKYO COMPANY LIMITED (JA) | 1976-08-17 | — | — | US | disclosed |