SCHEMBL118112

SCHEMBL118112

O=C(C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)NC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MDM4 O15151 3/20 0.54
▸ TP53 P04637 3/20 0.54
▸ CASP3 P42574 2/20 0.50
▸ MDM2 Q00987 6/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ TLR2 O60603 2/20 0.46
▸ SLC17A5 Q9NRA2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15521126 1.00 MDM4 (0.54) MDM4TP53CASP3MDM2KMT2A
SCHEMBL29362168 1.00 MDM4 (0.54) MDM4TP53CASP3MDM2KMT2A
SCHEMBL31248559 1.00 MDM4 (0.54) MDM4TP53CASP3MDM2KMT2A
SCHEMBL8227161 1.00 MDM4 (0.54) MDM4TP53CASP3MDM2KMT2A
SCHEMBL29352034 1.00 MDM4 (0.54) MDM4TP53CASP3MDM2KMT2A
SCHEMBL20592813 0.94 MDM2 (0.51) MDM4TP53CASP3MDM2KMT2A
SCHEMBL20592811 0.94 MDM2 (0.51) MDM4TP53CASP3MDM2KMT2A
SCHEMBL29759385 0.94 MDM2 (0.51) MDM4TP53CASP3MDM2KMT2A
SCHEMBL29493132 0.92 MDM2 (0.53) MDM4TP53CASP3MDM2TLR2
SCHEMBL8226910 0.92 MDM4 (0.50) MDM4TP53CASP3KMT2ATLR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748847-A1 PEPTIDE COMPLEX HAVING VEGFR -2 AGONIST ACTIVITY Peptidream Inc (JP) 2026-05-27 — — EP disclosed
EP-4698551-A1 NOVEL SMALL MOLECULE AGONISTS OF INSULIN RECEPTOR (INSR) AS ANTI-DIABETES DRUGS The University of Hong Kong (CN) 2026-02-25 — — EP disclosed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 — — US disclosed
EP-4548937-A1 ANTIBODY-DRUG COMPLEX Eisai R&D Management Co., Ltd. (JP) 2025-05-07 — — EP disclosed
WO-2024217497-A1 NOVEL SMALL MOLECULE AGONISTS OF INSULIN RECEPTOR (INSR) AS ANTI-DIABETES DRUGS THE UNIVERSITY OF HONG KONG (CN) 2024-10-24 — — WO disclosed
US-20240218022-A1 ANTI-VISTA MACROCYCLIC PEPTIDES AND COMPOSITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-04 — — US disclosed
US-12018093-B2 Hemiasterlin derivatives and antibody-drug conjugates including same Sumitomo Pharma Co., Ltd. (JP) 2024-06-25 — — US disclosed
US-20240148895-A1 ANTIBODY-DRUG CONJUGATE EISAI R&D MANAGEMENT CO., LTD. (JP) 2024-05-09 — — US disclosed
US-20240076311-A1 METHOD FOR SYNTHESIZING PEPTIDE THIOESTERS AND HEAD-TO-TAIL AMIDE CYCLIC PEPTIDE THEREOF JIANGSU GENSCRIPT BIOTECH CO., LTD. (CN) 2024-03-07 — — US disclosed
WO-2024043319-A1 ANTIBODY-DRUG COMPLEX エーザイ・アール・アンド・ディー・マネジメント株式会社 2024-02-29 — — WO disclosed
US-20070238669-A1 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY 2007-10-11 — — US disclosed
US-7238671-B2 Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-03 — — US disclosed
US-7238670-B2 Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-03 — — US disclosed
US-7238671-B2 Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-03 — — US disclosed
US-20070149763-A1 Beta secretase exosite binding peptides and methods for identifying beta secretase modulators BRISTOL-MYERS SQUIBB COMPANY 2007-06-28 — — US disclosed
EP-1697344-A2 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2006-09-06 — — EP disclosed
EP-1626095-A1 Fluorescence-based kinetic determination of transglutaminase activity N-Zyme BioTec GmbH (DE) 2006-02-15 — — EP disclosed
US-20050148623-A1 Prevent reproduct of aids virus ABBVIE INC. 2005-07-07 — — US disclosed
WO-2005058841-A2 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2005-06-30 — — WO disclosed
US-6528655-B1 Hydroxyphenyl diamido derivatives PHARMACOR, INC. (CA) 2003-03-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238669-A1 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS GLP1R, GIPR, IAPP MDM4 4711/4885TP53 4432/4885CASP3 1775/4885
US-20240076311-A1 METHOD FOR SYNTHESIZING PEPTIDE THIOESTERS AND HEAD-TO-TAIL AMIDE CYCLIC PEPTIDE THEREOF VIP, CETP, PITHD1 MDM4 3923/4885TP53 954/4885CASP3 2243/4885
US-20050148623-A1 Prevent reproduct of aids virus SERPINB1, PRSS1, SERPINA3 MDM4 1135/4885TP53 1321/4885CASP3 258/4885
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES FCGR2A, FCGR3B, FCGR1A MDM4 4586/4885TP53 356/4885CASP3 3963/4885
US-20240218022-A1 ANTI-VISTA MACROCYCLIC PEPTIDES AND COMPOSITIONS VIP, SGTA, NGLY1 MDM4 4261/4885TP53 1583/4885CASP3 535/4885
US-20240148895-A1 ANTIBODY-DRUG CONJUGATE ANTXR2, FCGR1A, HAX1 MDM4 4385/4885TP53 4379/4885CASP3 3511/4885
US-20070149763-A1 Beta secretase exosite binding peptides and methods for identifying beta secretase modulators BACE1, BACE2, APP MDM4 1923/4885TP53 1686/4885CASP3 1428/4885
US-12018093-B2 Hemiasterlin derivatives and antibody-drug conjugates including same FCGRT, QARS1, INHA MDM4 2717/4885TP53 1516/4885CASP3 4334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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