Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | FABP3 | P05413 | 1/20 | 0.30 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11816652 | 0.85 | GABRG2 (0.36) | MKNK1MKNK2GABRG2GABRB3GABRA5 | |
| SCHEMBL11822511 | 0.83 | GABRG2 (0.36) | MKNK1MKNK2GABRG2GABRB3GABRA5 | |
| SCHEMBL11816777 | 0.77 | FABP4 (0.36) | MKNK1MKNK2GABRG2GABRB3GABRA5 | |
| SCHEMBL11816596 | 0.75 | CYP1A2 (0.43) | GABRG2GABRB3GABRA5GABRA1L3MBTL1 | |
| SCHEMBL11818894 | 0.75 | TSHR (0.40) | L3MBTL1SLC6A2CYP2C19 | |
| SCHEMBL16516540 | 0.73 | L3MBTL1 (0.44) | MAT2AL3MBTL1ATMCYP2C19FABP3 | |
| SCHEMBL11820624 | 0.72 | FAAH (0.40) | L3MBTL1 | |
| SCHEMBL11824198 | 0.70 | CYP2A6 (0.40) | ATM | |
| SCHEMBL11822572 | 0.68 | KDR (0.44) | — | |
| SCHEMBL11821610 | 0.66 | NPC1 (0.46) | MKNK1MKNK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3961062-A | Pharmaceutical composition containing 1-(imidazole-1-yl)-isoquinolines and method of treating hyperlipemia | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-01 | — | — | US | disclosed |