Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 8/20 | 0.33 |
| ▸ | FLT1 | P17948 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11826476 | 0.91 | MAPT (0.35) | MAPTHTTLMNAPOLBKDM4E | |
| SCHEMBL11827838 | 0.90 | MAPT (0.39) | ESR1MAPTHTTLMNAPOLB | |
| SCHEMBL11825945 | 0.88 | MEN1 (0.37) | MAPTHTTALDH1A1KDRMEN1 | |
| SCHEMBL11834806 | 0.78 | ALDH1A1 (0.33) | MAPTHTTKDM4EALDH1A1KMT2A | |
| SCHEMBL11824852 | 0.76 | KDM4E (0.36) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11834796 | 0.76 | ALDH1A1 (0.34) | MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL11825801 | 0.75 | TDP1 (0.37) | MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL11822532 | 0.71 | MAPT (0.46) | MAPTLMNAALDH1A1KDRFLT1 | |
| SCHEMBL11827166 | 0.69 | MAPT (0.42) | MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL11824162 | 0.67 | MAPT (0.52) | MAPTLMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3978057-A | HYPOTENSIVE AGENTS | SANDOZ, INC. (US) | 1976-08-31 | — | — | US | disclosed |