SCHEMBL1185484

SCHEMBL1185484

Cc1ccc(I)cc1[N+](=O)[O-]

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.60
ALDH1A1 P00352 3/20 0.60
CYP3A4 P08684 2/20 0.60
RECQL P46063 1/20 0.60
HSD17B10 Q99714 1/20 0.52
CES2 O00748 1/20 0.49
CES1 P23141 1/20 0.49
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
MAPT P10636 2/20 0.45
LMNA P02545 1/20 0.45
MAPK1 P28482 1/20 0.45
CRHBP P24387 1/20 0.45
CRHR2 Q13324 1/20 0.45
MCOLN3 Q8TDD5 1/20 0.45
PPIA P62937 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1665203 0.85 ALDH1A1 (0.46) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL6693481 0.83 MAPT (0.56) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL6840900 0.80 TSHR (0.56) TSHRALDH1A1CYP3A4HSD17B10MEN1
SCHEMBL171914 0.78 TSHR (0.72) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL29613904 0.78 TSHR (0.72) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL14371934 0.78 MAPT (0.43) TSHRALDH1A1CYP3A4HSD17B10CES1
SCHEMBL1665978 0.78 PARP1 (0.56) TSHRALDH1A1CYP3A4MEN1KMT2A
SCHEMBL7190826 0.78 TSHR (0.64) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL2340894 0.77 ALDH1A1 (0.49) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL23293742 0.77 TSHR (0.62) TSHRALDH1A1CYP3A4RECQLHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028330-A1 HETEROARYL CARBOXAMIDE AND RELATED GPR84 ANTAGONISTS AND USES THEREOF LIMINAL BIOSCIENCES LTD (GB) 2026-01-29 US disclosed
EP-4565568-A1 HETEROARYL CARBOXAMIDE AND RELATED GPR84 ANTAGONISTS AND USES THEREOF Liminal Biosciences Limited (GB) 2025-06-11 EP disclosed
CN-120019047-A Heteroaryl carboxamides and related GPR84 antagonists and uses thereof 里米诺生物科学有限公司 2025-05-16 CN disclosed
WO-2024028363-A1 HETEROARYL CARBOXAMIDE AND RELATED GPR84 ANTAGONISTS AND USES THEREOF Liminal Biosciences Limited (GB) 2024-02-08 WO disclosed
WO-2023202625-A1 FGFR2 INHIBITOR AND METHOD FOR USING SAME 深圳福沃药业有限公司 2023-10-26 WO disclosed
CN-116903628-A FGFR2 inhibitors and methods of use 深圳福沃药业有限公司 2023-10-20 CN disclosed
CN-116813475-A Halogenated synthesis method of aromatic ring compound 北京大学 2023-09-29 CN disclosed
WO-2022220625-A1 PROTEIN DEGRADER CONJUGATES AND USE THEREOF 주식회사 레고켐바이오사이언스 2022-10-20 WO disclosed
CN-113387823-B Anthranilic acid and derivative thereof, and synthetic method and application thereof 华东师范大学 2022-07-08 CN disclosed
CN-112939948-B Novel quinazoline-containing compound, intermediate and application thereof 苏州美诺医药科技有限公司 2022-05-17 CN disclosed
US-5844110-A Synthetic triple helix-forming compound precursors UNIVERSITY OF NEBRASKA BOARD OF REGENTS (US) 1998-12-01 US disclosed
EP-0869787-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1998-10-14 EP disclosed
WO-1997037999-A1 SYNTHETIC TRIPLE HELIX-FORMING COMPOUNDS UNIVERSITY OF NEBRASKA BOARD OF REGENTS (US) 1997-10-16 WO disclosed
WO-1997024124-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-07-10 WO disclosed
WO-1997024122-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-07-10 WO disclosed
WO-1997024119-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-07-10 WO disclosed
WO-1996023777-A1 SYNTHETIC TRIPLE HELIX-FORMING COMPOUNDS UNIVERSITY OF NEBRASKA BOARD OF REGENTS (US) 1996-08-08 WO disclosed
US-4812162-A PLANT GROWTH REGULATORS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-03-14 US disclosed
EP-0274825-A2 Indole derivatives and their uses in agriculture ZENECA LIMITED (GB) 1988-07-20 EP disclosed
US-4020107-A ACIDIC PHOSPHORUS COMPOUND DEHALOGENATION INHIBITOR E. I. DU PONT DE NEMOURS AND CO. (US) 1977-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028330-A1 HETEROARYL CARBOXAMIDE AND RELATED GPR84 ANTAGONISTS AND USES THEREOF GPR84, GPR88, GPR68 TSHR 690/4885ALDH1A1 1033/4885CYP3A4 1491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.