Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.83 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.83 |
| ▸ | PGR | P06401 | 5/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 2/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | AR | P10275 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14114135 | 1.00 | LMNA (0.83) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL124165 | 0.92 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL28971361 | 0.92 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL15975096 | 0.92 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL11422147 | 0.92 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL13985471 | 0.92 | LMNA (0.81) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL1973547 | 0.92 | HIF1A (0.81) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL14884636 | 0.92 | HIF1A (0.87) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL13181589 | 0.91 | LMNA (0.80) | LMNAHIF1ACYP3A4NR3C1PGR | |
| SCHEMBL13595537 | 0.91 | LMNA (0.80) | LMNAHIF1ACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | ALCON INC. (CH) | 2020-03-05 | — | — | US | disclosed |
| US-7645747-B2 | Improved pharmacokinetic properties, oral bioavailability; side effect reduction | GILEAD SCIENCES, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090318396-A1 | CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | GILEAD SCIENCES, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | CANNIZZARO CARINA | 2009-09-10 | — | — | US | disclosed |
| US-7470724-B2 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | PHOSPHO1, NFATC1, IFNG | LMNA 4759/4885HIF1A 3718/4885CYP3A4 3919/4885 |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | LMNA 2591/4885HIF1A 1199/4885CYP3A4 1894/4885 |
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | GRK1, TNK2, CYP11B2 | LMNA 1670/4885HIF1A 3238/4885CYP3A4 3148/4885 |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | LMNA 1670/4885HIF1A 3238/4885CYP3A4 3148/4885 |
| US-20090318396-A1 | CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | ADRB1, ADRB2, ADRB3 | LMNA 1497/4885HIF1A 3625/4885CYP3A4 862/4885 |
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | LMNA 1670/4885HIF1A 3238/4885CYP3A4 3148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.