SCHEMBL1189211

SCHEMBL1189211

CC1=C(C)C(=O)C(CCC(C)(O)C(=O)NCCc2ccc(O)cc2)=C(C)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
F13A1 P00488 1/20 0.46
ESRRG P62508 4/20 0.44
ESRRB O95718 3/20 0.44
ALOX15 P16050 2/20 0.41
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP1A2 P05177 1/20 0.38
GAA P10253 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38
GFER P55789 1/20 0.38
ABCG2 Q9UNQ0 1/20 0.38
TMEM97 Q5BJF2 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
PTPN2 P17706 1/20 0.37
PTPN1 P18031 1/20 0.37
CDC25B P30305 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2059268 0.89 HPGD (0.43) ALOX15NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL2058849 0.89 CYP1A2 (0.44) NPC1RAB9ASMN1; SMN2CYP1A2GAA
SCHEMBL1188414 0.89 MMP8 (0.47) ESRRGALOX15NPC1RAB9ASMN1; SMN2
SCHEMBL2059289 0.81 SMN1; SMN2 (0.46) NPC1RAB9ASMN1; SMN2GAAMAPT
SCHEMBL1189372 0.81 CNR1 (0.42) ALOX15MAPT
SCHEMBL2059454 0.81 ALOX15 (0.45) ALOX15CYP2D6MAPTCYP2C19PTPN2
SCHEMBL2059249 0.81 ALOX15 (0.45) ALOX15GAAPTPN2PTPN1CDC25B
SCHEMBL1187752 0.81 ALOX15 (0.45) ALOX15CYP2D6MAPTCYP2C19PTPN2
SCHEMBL2059205 0.81 ALOX15 (0.45) ALOX15CYP2D6MAPTCYP2C19PTPN2
SCHEMBL17416759 0.81 ALOX15 (0.45) ALOX15PTPN2PTPN1CDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210179542-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES BIOELECTRON TECHNOLOGY CORPORATION 2021-06-17 US claimed
US-20190270699-A1 4-(P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2019-09-05 US claimed
US-20160075638-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2016-03-17 US claimed
EP-2220030-B1 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES EDISON PHARMACEUTICALS INC (US) 2016-01-13 EP claimed
US-9169196-B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases EDISON PHARMACEUTICALS, INC. (US) 2015-10-27 US claimed
US-20130289034-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2013-10-31 US claimed
US-8519001-B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases EDISON PHARMACEUTICALS, INC. (US) 2013-08-27 US claimed
US-20120122934-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2012-05-17 US claimed
US-7968746-B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases EDISON PHARMACEUTICALS, INC. (US) 2011-06-28 US claimed
EP-2220030-A2 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES Edison Pharmaceuticals, Inc. (US) 2010-08-25 EP claimed
WO-2009061744-A2 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES EDISON PHARMACEUTICALS, INC. (US) 2009-05-14 WO claimed
US-20090118257-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2009-05-07 US claimed
EP-3733642-B1 4-(P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS INC (US) 2024-05-08 EP disclosed
US-11840497-B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases PTC THERAPEUTICS, INC. (US) 2023-12-12 US disclosed
US-20210322337-A1 TREATMENT OF OXIDATIVE STRESS DISORDERS INCLUDING CONTRAST NEPHROPATHY, RADIATION DAMAGE AND DISRUPTIONS IN THE FUNCTION OF RED CELLS PTC THERAPEUTICS, INC. 2021-10-21 US disclosed
US-20210179542-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES BIOELECTRON TECHNOLOGY CORPORATION 2021-06-17 US disclosed
WO-2010045220-A1 TREATMENT OF OXIDATIVE STRESS DISORDERS INCLUDING CONTRAST NEPHROPATHY, RADIATION DAMAGE AND DISRUPTIONS IN THE FUNCTION OF RED CELLS EDISON PHARMACEUTICALS, INC. (US) 2010-04-22 WO disclosed
WO-2009111543-A2 TREATMENT OF HEARING AND BALANCE IMPAIRMENTS WITH REDOX-ACTIVE THERAPEUTICS EDISON PHARMACEUTICALS, INC. (US) 2009-09-11 WO disclosed
WO-2009061744-A2 4- (P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES EDISON PHARMACEUTICALS, INC. (US) 2009-05-14 WO disclosed
US-20090118257-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES PTC THERAPEUTICS, INC. 2009-05-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190270699-A1 4-(P-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 803/4885F13A1 1167/4885ESRRG 2873/4885
US-20130289034-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-20160075638-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-11840497-B2 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-20120122934-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-20210179542-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-20090118257-A1 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES FH, NLN, ACAA2 KDM4E 807/4885F13A1 1235/4885ESRRG 2746/4885
US-20210322337-A1 TREATMENT OF OXIDATIVE STRESS DISORDERS INCLUDING CONTRAST NEPHROPATHY, RADIATION DAMAGE AND DISRUPTIONS IN THE FUNCTION OF RED CELLS GPX4, TXN2, TXNRD1 KDM4E 4648/4885F13A1 1703/4885ESRRG 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.