Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15121608 | 1.00 | GPR88 (0.37) | GPR88KMT2ASMN1; SMN2MEN1PKM | |
| SCHEMBL15121643 | 0.90 | KMT2A (0.39) | GPR88KMT2ASMN1; SMN2MEN1PKM | |
| SCHEMBL15134967 | 0.88 | GPR88 (0.36) | GPR88KMT2ASMN1; SMN2MEN1PKM | |
| SCHEMBL15121973 | 0.81 | KMT2A (0.41) | KMT2ASMN1; SMN2LMNATDP1 | |
| SCHEMBL15121577 | 0.80 | FFAR1 (0.40) | GPR88FFAR1GAAHTTITGB3 | |
| SCHEMBL11904852 | 0.75 | TDP1 (0.35) | GPR88SMN1; SMN2TDP1FKBP1A | |
| SCHEMBL11903483 | 0.72 | LMNA (0.41) | GPR88FFAR1GAAHTTITGB3 | |
| SCHEMBL18343122 | 0.69 | HSD17B10 (0.50) | KMT2ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL11903585 | 0.68 | KCNH2 (0.41) | GPR88KDM4E | |
| SCHEMBL11903579 | 0.68 | GPR88 (0.39) | GPR88FFAR1GAAHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |