Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15134967 | 0.81 | GPR88 (0.36) | GPR88SMN1; SMN2DPP4FKBP1APDE3B | |
| SCHEMBL6846774 | 0.77 | LTA4H (0.44) | GPR88PPARGPPARAMAPTPARP10 | |
| SCHEMBL11904813 | 0.75 | GPR88 (0.37) | TDP1GPR88SMN1; SMN2FKBP1A | |
| SCHEMBL15121608 | 0.75 | GPR88 (0.37) | TDP1GPR88SMN1; SMN2FKBP1A | |
| SCHEMBL31664398 | 0.65 | SMN1; SMN2 (0.43) | TDP1SMN1; SMN2MAPT | |
| SCHEMBL20382500 | 0.65 | HTT (0.51) | TDP1MAPTPARP10 | |
| SCHEMBL15121643 | 0.65 | KMT2A (0.39) | TDP1GPR88SMN1; SMN2DPP4 | |
| SCHEMBL353033 | 0.65 | MTNR1A (0.53) | GPR88SMN1; SMN2MAPTPARP10MTNR1A | |
| SCHEMBL11904853 | 0.64 | GPR88 (0.43) | TDP1GPR88SMN1; SMN2PPARGPPARA | |
| SCHEMBL28884153 | 0.63 | ABL1 (0.39) | TDP1SMN1; SMN2ABL1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |