Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 3/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 3/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25431949 | 0.81 | ORAI1 (0.37) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL2143307 | 0.80 | CYP3A4 (0.40) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL28545103 | 0.80 | ORAI1 (0.39) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL3734405 | 0.79 | ALDH1A1 (0.36) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL9941370 | 0.78 | AKT1 (0.40) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL9941405 | 0.77 | TRPV6 (0.37) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL363448 | 0.74 | TRPV6 (0.46) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL28390937 | 0.73 | ALOX15 (0.47) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL1722636 | 0.72 | PCSK9 (0.45) | ORAI1ORAI2ORAI3TRPV6PCSK9 | |
| SCHEMBL1660275 | 0.72 | TRPV6 (0.44) | ORAI1ORAI2ORAI3TRPV6PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | disclosed |