Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 4/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 3/20 | 0.46 |
| ▸ | ORAI3 | Q9BRQ5 | 3/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117263 | 0.82 | ALDH1A1 (0.45) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| Benzene SCHEMBL10445518 | 0.82 | ALDH1A1 (0.45) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1756154 | 0.79 | KDM4E (0.47) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1722636 | 0.79 | PCSK9 (0.45) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1129435 | 0.79 | TRPV6 (0.44) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1660275 | 0.79 | TRPV6 (0.44) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1491911 | 0.79 | PCSK9 (0.41) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL4726793 | 0.78 | TSHR (0.45) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL18550249 | 0.77 | TSHR (0.46) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| Hydrochloric Acid SCHEMBL2526776 | 0.77 | KMT2A (0.45) | TRPV6ORAI1ORAI2ORAI3PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | claimed |
| JP-2011526420-A | — | — | 2011-10-06 | — | — | JP | claimed |
| WO-2011043817-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | WO | claimed |
| EP-2307398-A1 | POLYMERISABLE COMPOUNDS FOR MAKING OPTO-ELECTRONIC DEVICES | IMEC (BE) | 2011-04-13 | — | — | EP | claimed |
| WO-2010000504-A1 | POLYMERISABLE COMPOUNDS FOR MAKING OPTO-ELECTRONIC DEVICES | INTERUNIVERSITAIR MICROELEKTRONICA CENTRUM (BE) | 2010-01-07 | — | — | WO | claimed |
| US-12258331-B2 | Pyrimidine derivative and preparation process and use thereof | GUANGDONG LEWWIN PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2025-03-25 | — | — | US | disclosed |
| US-12202820-B2 | Pyrimidine derivative and preparation process and use thereof | GUANGDONG LEWWIN PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2025-01-21 | — | — | US | disclosed |
| CN-119264347-A | Degradable flame-retardant phenolic aerogel and preparation method and application thereof | 中车成型科技(青岛)有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-116239562-B | Method for synthesizing doxepin hydrochloride by taking benzofuranone as raw material | 江苏师范大学 | 2024-12-31 | — | — | CN | disclosed |
| US-12168654-B2 | Pyrimidine derivative containing one deuterium atom and preparation process and use thereof | GUANGDONG LEWWIN PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2024-12-17 | — | — | US | disclosed |
| WO-2024091983-A1 | THERAPEUTIC AGENTS FOR ENHANCING EPITHELIAL AND/OR ENDOTHELIAL BARRIER FUNCTION | ARTUS THERAPEUTICS, INC. (US) | 2024-05-02 | — | — | WO | disclosed |
| US-20230365532-A1 | PYRIMIDINE DERIVATIVE AND PREPARATION PROCESS AND USE THEREOF | Guangdong CS-Lewwin Drug Research Co., Ltd. (CN) | 2023-11-16 | — | — | US | disclosed |
| EP-1620086-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION | Warner-Lambert Company LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2005081954-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
| WO-2005035551-A2 | INHIBITORS OF PROTEINS THAT BIND PHOSPHORYLATED MOLECULES | INCYTE CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |
| US-6875780-B2 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | disclosed |
| WO-2004091604-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040209936-A1 | Compounds that modulate PPAR activity and methods of preparation | BRATTON LARRY D (US) | 2004-10-21 | — | — | US | disclosed |
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12202820-B2 | Pyrimidine derivative and preparation process and use thereof | MET, HCCS, MTR | TRPV6 4203/4885ORAI1 3092/4885ORAI2 4056/4885 |
| US-20040209936-A1 | Compounds that modulate PPAR activity and methods of preparation | PPARA, PPARG, PPARD | TRPV6 1367/4885ORAI1 4268/4885ORAI2 4275/4885 |
| US-20230365532-A1 | PYRIMIDINE DERIVATIVE AND PREPARATION PROCESS AND USE THEREOF | MTR, HCCS, MET | TRPV6 3944/4885ORAI1 3365/4885ORAI2 3782/4885 |
| US-12258331-B2 | Pyrimidine derivative and preparation process and use thereof | MTR, HCCS, MET | TRPV6 3944/4885ORAI1 3365/4885ORAI2 3782/4885 |
| US-12168654-B2 | Pyrimidine derivative containing one deuterium atom and preparation process and use thereof | DUT, TYMP, DCTD | TRPV6 4444/4885ORAI1 4213/4885ORAI2 4462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.