Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13312285 | 0.85 | MGLL (0.44) | LMNAPOLBMGLLALDH1A1MEN1 | |
| SCHEMBL3433408 | 0.84 | MGLL (0.43) | LMNAMGLLHDAC6ALDH1A1MEN1 | |
| SCHEMBL973413 | 0.84 | ALOX15 (0.45) | MGLLALDH1A1KMT2AKDM4ETDP1 | |
| SCHEMBL6361138 | 0.84 | ALDH1A1 (0.47) | POLBMGLLRIPK1HDAC6ALDH1A1 | |
| SCHEMBL125418 | 0.83 | KDM4E (0.47) | LMNAMGLLHDAC6ALDH1A1MEN1 | |
| SCHEMBL249051 | 0.82 | CNR2 (0.54) | POLBHDAC6GLAEGLN1CYP1A2 | |
| SCHEMBL249434 | 0.82 | SORT1 (0.59) | LMNAALDH1A1KMT2AGLAKDM4E | |
| SCHEMBL123859 | 0.82 | MGLL (0.42) | LMNAMGLLHDAC6ALDH1A1MEN1 | |
| SCHEMBL5717652 | 0.82 | PARP1 (0.46) | LMNAMGLLMEN1KMT2AKDM4E | |
| SCHEMBL619508 | 0.81 | GLA (0.60) | LMNAHDAC6KMT2AGLACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732105-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-10 | — | — | US | disclosed |
| US-9217000-B2 | Targeted nitroxide agents | Univerisyt of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-01-16 | — | — | US | disclosed |
| US-20120207687-A1 | TOPICAL FORMULATIONS OF TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120207687-A1 | TOPICAL FORMULATIONS OF TARGETED NITROXIDE AGENTS | NOX1, OGG1, NOX5 | LMNA 2306/4885POLB 592/4885PLK1 1420/4885 |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | LMNA 2142/4885POLB 1683/4885PLK1 464/4885 |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | LMNA 2142/4885POLB 1683/4885PLK1 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.