SCHEMBL11919002

SCHEMBL11919002

O=CNc1cc(F)c(F)c(B(O)O)c1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
EGFR P00533 1/20 0.30
RAPGEF4 Q8WZA2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1187384 0.80 ALDH1A1 (0.42) ALDH1A1EGFRRAPGEF4
SCHEMBL4547744 0.75 LMNA (0.46) ALDH1A1
SCHEMBL29440748 0.68 CES2 (0.43) RAPGEF4
SCHEMBL1513608 0.68 CES2 (0.43) RAPGEF4
SCHEMBL12433524 0.66 RAPGEF4 (0.36) ALDH1A1RAPGEF4
SCHEMBL1588979 0.66 ALDH1A1 (0.55) ALDH1A1
SCHEMBL2993734 0.65 CES2 (0.33)
SCHEMBL30502469 0.65 CES2 (0.33)
SCHEMBL429152 0.65 ALDH1A1 (0.44) ALDH1A1EGFRRAPGEF4
SCHEMBL20296440 0.65 ALDH1A1 (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8241574-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2012-08-14 US disclosed
US-20110286064-A1 OPHTHALMIC DEVICE COMPRISING A HOLOGRAPHIC SENSOR BURLES BARRY (GB) 2011-11-24 US disclosed
US-7998412-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-08-16 US disclosed
US-20090021697-A1 Ophthalmic Device Comprising a Holographic Sensor SMART HOLOGRAMS LIMITED (GB) 2009-01-22 US disclosed