Tanshinone Iib

Tanshinone Iib

SCHEMBL11945767

Cc1coc2c1C(=O)C(=O)c1c-2ccc2c1CCCC2(C)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EED O75530 5/20 1.00
▸ SUZ12 Q15022 5/20 1.00
▸ EZH2 Q15910 5/20 1.00
▸ HIF1A Q16665 2/20 0.73
▸ EPAS1 Q99814 2/20 0.73
▸ KDM4E B2RXH2 1/20 0.73
▸ MEN1 O00255 1/20 0.73
▸ CES2 O00748 1/20 0.73
▸ APAF1 O14727 1/20 0.73
▸ TERT O14746 1/20 0.73
▸ ALDH1A1 P00352 1/20 0.73
▸ LMNA P02545 1/20 0.73
▸ TP53 P04637 1/20 0.73
▸ POLB P06746 1/20 0.73
▸ MAPT P10636 1/20 0.73
▸ AKR1B1 P15121 1/20 0.73
▸ HPGD P15428 1/20 0.73
▸ ALOX12 P18054 1/20 0.73
▸ CES1 P23141 1/20 0.73
▸ APEX1 P27695 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tanshinone Iib SCHEMBL14417728 1.00 EED (1.00) EEDSUZ12EZH2HIF1AEPAS1
Isotanshinone Iib SCHEMBL30381469 0.92 EED (0.85) EEDSUZ12EZH2HIF1AEPAS1
SCHEMBL17663613 0.87 EED (0.77) EEDSUZ12EZH2HIF1AEPAS1
SCHEMBL14417696 0.86 EED (0.76) EEDSUZ12EZH2HIF1AEPAS1
SCHEMBL16152283 0.86 EED (0.76) EEDSUZ12EZH2HIF1AEPAS1
SCHEMBL16152326 0.85 EED (0.78) EEDSUZ12EZH2HIF1AEPAS1
Tanshinone Iia SCHEMBL2026738 0.84 EED (1.00) EEDSUZ12EZH2HIF1AEPAS1
Methyl Tanshinonate SCHEMBL14417730 0.80 EED (1.00) EEDSUZ12EZH2HIF1AEPAS1
Methyl Tanshinonate SCHEMBL16152293 0.80 EED (1.00) EEDSUZ12EZH2HIF1AEPAS1
Przewaquinone A SCHEMBL16152272 0.78 IDO1 (1.00) EEDSUZ12EZH2HIF1AEPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250170252-A1 QUINONE PROTECTED FORMS AND CONJUGATES CAMBRIDGE ENTERPRISE LIMITED (GB) 2025-05-29 — — US claimed
CN-119912517-A Tanshinone IIB sodium sulfonate derivative and refining method thereof 上海上药第一生化药业有限公司 2025-05-02 — — CN claimed
EP-4532480-A1 QUINONE PROTECTED FORMS AND CONJUGATES Cambridge Enterprise Limited (GB) 2025-04-09 — — EP claimed
CN-118924861-A Hair-growing and hair-blackening smearing liquid rich in trace elements and proteins 丁桂芳 2024-11-12 — — CN claimed
CN-118021812-A Nidaminib targeting compositions 北京睿创康泰医药研究院有限公司 2024-05-14 — — CN claimed
CN-117924405-A Refining method of tanshinone IIA sodium sulfonate 上海上药第一生化药业有限公司 2024-04-26 — — CN claimed
CN-117899176-A Chinese medicinal composition for treating coronary heart disease and angina pectoris and preparation method thereof 陕西步长制药有限公司 2024-04-19 — — CN claimed
WO-2023227757-A1 QUINONE PROTECTED FORMS AND CONJUGATES CAMBRIDGE ENTERPRISE LIMITED (GB) 2023-11-30 — — WO claimed
CN-115184533-B LC-MS method for quantitatively detecting golden bell oral liquid 山东宏济堂制药集团股份有限公司 2023-06-20 — — CN claimed
CN-115184533-A LC-MS method for quantitatively detecting gold scallop oral liquid 山东宏济堂制药集团股份有限公司 2022-10-14 — — CN claimed
CN-114984154-A Traditional Chinese medicine formula Xinmaitong tablets and preparation method thereof 唐祖宣 2022-09-02 — — CN claimed
CN-121991159-A Method for selectively synthesizing tanshinone IIB sodium sulfonate and tanshinone IIB 上海上药第一生化药业有限公司 2026-05-08 — — CN disclosed
CN-121991159-A Method for selectively synthesizing tanshinone IIB sodium sulfonate and tanshinone IIB 上海上药第一生化药业有限公司 2026-05-08 — — CN disclosed
EP-4587011-A1 COMBINATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING A PI3K/AKT/MTOR PATHWAY INHIBITING COMPOUND Royal Holloway & Bedford New College (GB) 2025-07-23 — — EP disclosed
CN-120189360-A Facial mask, preparation method and use method thereof 北京同仁堂麦尔海生物技术有限公司 2025-06-24 — — CN disclosed
EP-2786989-A1 2-ALKYL-OR-ARYL-SUBSTITUTED TANSHINONE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREOF Hangzhou Bensheng Pharmaceutical Co., Ltd. (CN) 2014-10-08 — — EP disclosed
EP-2786990-A1 2-AMINATED METHYLENE OR 2-ESTERIFIED METHYLENE TANSHINONE DERIVATIVES, AND PREPARATION METHOD AND APPLICATION THEREOF Hangzhou Bensheng Pharmaceutical Co., Ltd. (CN) 2014-10-08 — — EP disclosed
WO-2014138357-A1 NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE THE UNIVERSITY OF AKRON (US) 2014-09-12 — — WO disclosed
US-8227426-B2 Chiral complexes of ascorbic acid with natural antioxidant and anti-inflammatory ketones including aloe, citrus, ginger, and mango for skin and hair care ISLAND KINETICS INC. (US) 2012-07-24 — — US disclosed
US-20110059907-A1 Chiral Complexes of Ascorbic Acid with Natural Antioxidant and Anti-Inflammatory Ketones Including Aloe, Citrus, Ginger, and Mango for Skin and Hair Care ISLAND KINETICS INC. (US) 2011-03-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110059907-A1 Chiral Complexes of Ascorbic Acid with Natural Antioxidant and Anti-Inflammatory Ketones Including Aloe, Citrus, Ginger, and Mango for Skin and Hair Care GLA, LPO, PLOD3 EED 3792/4885SUZ12 4449/4885EZH2 3088/4885
US-20250170252-A1 QUINONE PROTECTED FORMS AND CONJUGATES NQO1, SQOR, GSTP1 EED 116/4885SUZ12 1039/4885EZH2 368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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