Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1197042 | 1.00 | HTR1A (0.53) | HTR1AALDH1A1TACR1MTNR1AMTNR1B | |
| SCHEMBL2013301 | 0.83 | MTNR1A (0.58) | ALDH1A1TACR1MTNR1AMTNR1BKMT2A | |
| Hydrochloric Acid SCHEMBL28174732 | 0.82 | MTNR1A (0.57) | ALDH1A1TACR1MTNR1AMTNR1BKMT2A | |
| Hydrochloric Acid SCHEMBL28174730 | 0.82 | MTNR1A (0.57) | ALDH1A1TACR1MTNR1AMTNR1BKMT2A | |
| SCHEMBL5165399 | 0.78 | HTR2A (0.64) | HTR1AALDH1A1TACR1MTNR1AMTNR1B | |
| SCHEMBL1195736 | 0.78 | HTR2A (0.64) | HTR1AALDH1A1TACR1MTNR1AMTNR1B | |
| SCHEMBL31291685 | 0.77 | HTR1A (0.60) | HTR1AALDH1A1MTNR1AMTNR1BNQO2 | |
| Hydrochloric Acid SCHEMBL6729297 | 0.77 | HTR2A (0.62) | HTR1AALDH1A1TACR1MTNR1AMTNR1B | |
| SCHEMBL1196780 | 0.77 | HTR2B (0.61) | HTR1AALDH1A1TACR1MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL6729301 | 0.77 | HTR2A (0.62) | HTR1AALDH1A1TACR1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | 4SC AG (DE) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | KIF5A, KIF5C, KIF5B | HTR1A 3485/4885ALDH1A1 3349/4885TACR1 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.