Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.66 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.65 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30061444 | 1.00 | KDR (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL15270551 | 0.87 | HDAC6 (0.79) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL29647754 | 0.87 | HDAC6 (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL19631488 | 0.87 | HDAC6 (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL29434873 | 0.87 | KDR (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL6260903 | 0.87 | KDR (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL28267081 | 0.86 | L3MBTL1 (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL30753823 | 0.86 | L3MBTL1 (1.00) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL15093487 | 0.86 | HDAC6 (0.77) | KDRL3MBTL1GAAHDAC6KMT2A | |
| SCHEMBL17552183 | 0.86 | HDAC6 (0.77) | KDRL3MBTL1GAAHDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475272-B1 | PHTHALAZINE DERIVATIVES AS INHIBITORS OF PARP1, PARP2 AND/OR TUBULIN USEFUL FOR THE TREATMENT OF CANCER | UNIV CALIFORNIA (US) | 2023-09-13 | — | — | EP | disclosed |
| US-20220402894-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | ATLASMEDX, INC. | 2022-12-22 | — | — | US | disclosed |
| CN-113336784-B | 3-substituted benzofluorenone or 3-substituted naphthofluorenone derivatives and synthesis method thereof | 上海大学 | 2022-11-18 | — | — | CN | disclosed |
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |
| CN-113336784-A | 3-substituted benzofluorenone or 3-substituted naphthofluorenone derivatives and synthesis method thereof | 上海大学 | 2021-09-03 | — | — | CN | disclosed |
| CN-111575731-B | Method for electrochemically synthesizing C5 and C7 dihalogenated quinoline amide derivatives | 浙江工业大学 | 2021-08-24 | — | — | CN | disclosed |
| US-11072600-B2 | Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-27 | — | — | US | disclosed |
| CN-111519204-B | Method for preparing N- (5-chloro-8-quinolyl) benzamide compound by adopting electrochemical microchannel reaction device | 南京工业大学 | 2021-06-29 | — | — | CN | disclosed |
| CN-111423372-B | Method for preparing N- (5-hydroxyquinoline-8-yl) benzamide compound by electrochemical microchannel reaction device | 南京工业大学 | 2021-04-27 | — | — | CN | disclosed |
| CN-111575731-A | Method for electrochemically synthesizing C5 and C7 dihalogenated quinoline amide derivatives | 浙江工业大学 | 2020-08-25 | — | — | CN | disclosed |
| US-10640493-B2 | Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-05-05 | — | — | US | disclosed |
| CN-107698586-B | Method for preparing pyridoquinazolinone compound by catalysis of copper compound | 广州大学 | 2020-02-07 | — | — | CN | disclosed |
| US-20190352283-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | ATLASMEDX, INC. | 2019-11-21 | — | — | US | disclosed |
| US-20190337928-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | ATLASMEDX, INC. | 2019-11-07 | — | — | US | disclosed |
| CN-109320497-A | A method of phenanthridines ketone compounds are prepared by copper compound induction | 广州大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-107698586-A | It is a kind of that the method for preparing Pyridine-quinazolinocompound compound is catalyzed by copper compound | 广州大学 | 2018-02-16 | — | — | CN | disclosed |
| EP-2675526-B1 | NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| US-9102688-B2 | Sulfonaminoquinoline hepcidin antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2015-08-11 | — | — | US | disclosed |
| US-20140364424-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2014-12-11 | — | — | US | disclosed |
| US-20120214803-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402894-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | PARP2, PARP12, PARP1 | KDR 1482/4885L3MBTL1 3567/4885GAA 2710/4885 |
| US-20190337928-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | PARP2, PARP12, PARP1 | KDR 1482/4885L3MBTL1 3567/4885GAA 2710/4885 |
| US-20120214803-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | HAMP, SLC40A1, FTH1 | KDR 3583/4885L3MBTL1 3925/4885GAA 1518/4885 |
| US-10640493-B2 | Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer | PARP2, PARP12, PARP1 | KDR 1398/4885L3MBTL1 2447/4885GAA 2139/4885 |
| US-11072600-B2 | Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer | PARP2, PARP12, PARP1 | KDR 1482/4885L3MBTL1 3567/4885GAA 2710/4885 |
| US-20140364424-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | HAMP, SLC40A1, FTH1 | KDR 3583/4885L3MBTL1 3925/4885GAA 1518/4885 |
| US-20190352283-A1 | Phthalazine Derivatives as Inhibitors of PARP1, PARP2, and/or Tubulin Useful for the Treatment of Cancer | PARP2, PARP12, PARP1 | KDR 1398/4885L3MBTL1 2447/4885GAA 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.