Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CTSV | O60911 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158787 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL18561544 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL25967805 | 0.92 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL11981103 | 0.92 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL10158905 | 0.92 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL10158790 | 0.92 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL11981121 | 0.92 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL20756272 | 0.91 | TSHR (0.33) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL11981124 | 0.90 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2AGSTP1IDO1 | |
| SCHEMBL10159028 | 0.88 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AGSTP1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170056528-A1 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF | MODERNATX, INC. | 2017-03-02 | — | — | US | disclosed |
| US-9428535-B2 | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof | MODERNA THERAPEUTICS, INC. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150337002-A1 | NUCLEOSIDE AND NUCLEOTIDE HAVING SULFONAMIDE STRUCTURE | SHIONOGI & CO., LTD. (JP) | 2015-11-26 | — | — | US | disclosed |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | BANK OF AMERICA, N.A. | 2015-03-19 | — | — | US | disclosed |
| US-8541562-B2 | Bridged artificial nucleoside and nucleotide | OSAKA UNIVERSITY (JP) | 2013-09-24 | — | — | US | disclosed |
| US-20130115272-A1 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF | modeRNA Therapeutics (US) | 2013-05-09 | — | — | US | disclosed |
| US-20120208991-A1 | BRIDGED ARTIFICIAL NUCLEOSIDE AND NUCLEOTIDE | OSAKA UNIVERSITY (JP) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170056528-A1 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF | ADAR, NT5C3B, NSUN2 | ALDH1A1 2620/4885MEN1 2176/4885KMT2A 1675/4885 |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | NSUN2, RNGTT, RNMT | ALDH1A1 3467/4885MEN1 3134/4885KMT2A 3113/4885 |
| US-20120208991-A1 | BRIDGED ARTIFICIAL NUCLEOSIDE AND NUCLEOTIDE | NCL, NSUN2, NSUN3 | ALDH1A1 3380/4885MEN1 4656/4885KMT2A 691/4885 |
| US-20150337002-A1 | NUCLEOSIDE AND NUCLEOTIDE HAVING SULFONAMIDE STRUCTURE | NSUN2, NR2E3, NR0B2 | ALDH1A1 4270/4885MEN1 2783/4885KMT2A 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.