Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | CDC7 | O00311 | 3/20 | 0.59 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.59 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL27657109 | 0.97 | MAPT (0.77) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL290128 | 0.91 | MAPT (0.69) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18003093 | 0.90 | MAPT (0.80) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6756856 | 0.87 | MAPT (0.75) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2886858 | 0.85 | MAPT (0.80) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14108960 | 0.84 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4740518 | 0.84 | ALDH1A1 (0.81) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12875919 | 0.84 | CDC7 (0.66) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL979633 | 0.84 | ALDH1A1 (1.00) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL299051 | 0.83 | CDC7 (0.64) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4570313-A2 | CYANOTRIAZOLE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2025-06-18 | — | — | EP | disclosed |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2024-05-23 | — | — | US | disclosed |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-02-13 | — | — | US | disclosed |
| EP-4219477-A1 | CYANOTRIAZOLE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2023-08-02 | — | — | EP | disclosed |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-03 | — | — | US | disclosed |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-03-09 | — | — | US | disclosed |
| US-10626095-B2 | Cyanotriazole compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-04-21 | — | — | US | disclosed |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2019-10-31 | — | — | US | disclosed |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2019-07-16 | — | — | US | disclosed |
| EP-2927219-B1 | 2-ARYL SELENAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2018-05-30 | — | — | EP | disclosed |
| CN-1816550-B | Indolyl derivatives substituted with a thiazole ring and their use as PPAR modulators | HOFFMANN LA ROCHE | 2010-04-28 | — | — | CN | disclosed |
| WO-2009123316-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2009-10-08 | — | — | WO | disclosed |
| EP-1644368-B1 | INDOLYL DERIVATIVES SUBSTITUTED WITH A THIAZOLE RING AND THEIR USE AS PPAR MODULATORS | HOFFMANN LA ROCHE (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-7235572-B2 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMAN-LA ROCHE INC. (US) | 2007-06-26 | — | — | US | disclosed |
| CN-1816550-A | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |
| EP-1644368-A1 | INDOLYL DERIVATIVES SUBSTITUTED WITH A THIAZOLE RING AND THEIR USE AS PPAR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005423-A1 | INDOLYL DERIVATIVES SUBSTITUTED WITH A THIAZOLE RING AND THEIR USE AS PPAR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-20 | — | — | WO | disclosed |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-01-06 | — | — | US | disclosed |
| EP-1368011-A1 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002067912-A2 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES OR CONDITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626095-B2 | Cyanotriazole compounds | CS, PC, ACAT1 | MAPT 2196/4885MEN1 3151/4885KMT2A 865/4885 |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | MAPT 4707/4885MEN1 4748/4885KMT2A 3888/4885 |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | PPARG, PPARA, PPARD | MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885 |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885 |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885 |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885 |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885 |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | MAPT 3099/4885MEN1 3902/4885KMT2A 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.