Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17842222 | 0.82 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2HTTCES2 | |
| SCHEMBL1513038 | 0.78 | ALDH1A1 (0.65) | RAB9ANPC1SMN1; SMN2POLBHTT | |
| SCHEMBL5359509 | 0.77 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2POLBHTT | |
| SCHEMBL31414638 | 0.77 | CES2 (0.77) | RAB9ANPC1SMN1; SMN2CES2CES1 | |
| SCHEMBL4823687 | 0.77 | CES2 (0.77) | RAB9ANPC1SMN1; SMN2CES2CES1 | |
| SCHEMBL1309846 | 0.76 | TUBB4A (0.50) | SMN1; SMN2LMNA | |
| SCHEMBL15628231 | 0.76 | PARP1 (0.54) | RAB9ANPC1SMN1; SMN2POLBHTT | |
| SCHEMBL24688551 | 0.75 | CES2 (0.56) | RAB9ANPC1SMN1; SMN2POLBHTT | |
| Hydrochloric Acid SCHEMBL27733557 | 0.75 | CES2 (0.74) | RAB9ANPC1SMN1; SMN2CES2CES1 | |
| SCHEMBL9520003 | 0.74 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2POLBCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1812112-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044753-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143366-A1 | CHEMICAL COMPOUNDS | ROCK2, ROCK1, ABL1 | RAB9A 480/4885NPC1 1091/4885SMN1; SMN2 3969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.