Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 5/20 | 0.37 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | DGKA | P23743 | 1/20 | 0.34 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14173627 | 0.98 | POLB (0.42) | POLBPOLA1CA12CA14CA2 | |
| SCHEMBL11894877 | 0.79 | TSHR (0.48) | CA12CA14TSHRMEN1RECQL | |
| SCHEMBL10803394 | 0.78 | AKR1B1 (0.44) | CES2CES1TSHRMEN1KMT2A | |
| SCHEMBL11554744 | 0.78 | CES2 (0.41) | CES2CES1TSHRMEN1KMT2A | |
| SCHEMBL8258829 | 0.77 | — | — | |
| SCHEMBL28619980 | 0.77 | TSHR (0.46) | POLBPOLA1CA12CA14CA2 | |
| SCHEMBL27730190 | 0.77 | TSHR (0.46) | CA12CA14TSHRMEN1RECQL | |
| SCHEMBL11416491 | 0.76 | GPR84 (0.46) | POLBCES2CES1TSHRMEN1 | |
| SCHEMBL10709580 | 0.76 | GPR84 (0.46) | POLBCES2CES1TSHRMEN1 | |
| SCHEMBL11879805 | 0.76 | CES2 (0.43) | CES2CES1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759583-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | TEVA SANTE (FR) | 2014-06-24 | — | — | US | disclosed |
| US-20130066111-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CEPHALON FRANCE (FR) | 2013-03-14 | — | — | US | disclosed |
| US-8318979-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2012-11-27 | — | — | US | disclosed |
| EP-1863760-B1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2012-10-03 | — | — | EP | disclosed |
| US-8183294-B2 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | Cephelon France (FR) | 2012-05-22 | — | — | US | disclosed |
| US-20120123161-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CEPHALON FRANCE (FR) | 2012-05-17 | — | — | US | disclosed |
| US-20110098505-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Thio-Substituted Arylmethanesulfinyl Derivatives by Asymmetric Oxidation | CEPHALON FRANCE (FR) | 2011-04-28 | — | — | US | disclosed |
| US-7915449-B2 | Contacting the corresponding sulfur compound with complex, bas and oxidizer; oxidation; isolation | CEPHALON FRANCE (FR) | 2011-03-29 | — | — | US | disclosed |
| US-7893111-B2 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE (FR) | 2011-02-22 | — | — | US | disclosed |
| US-7812193-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2010-10-12 | — | — | US | disclosed |
| US-7368591-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2008-05-06 | — | — | US | disclosed |
| US-7317126-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2008-01-08 | — | — | US | disclosed |
| EP-1863760-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2007-12-12 | — | — | EP | disclosed |
| EP-1663963-B1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006097814-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2006-09-21 | — | — | WO | disclosed |
| EP-1702915-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE (FR) | 2006-09-20 | — | — | EP | disclosed |
| US-20060205706-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE (FR) | 2006-09-14 | — | — | US | disclosed |
| US-20050222257-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050080256-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | TEVA SANTE (FR) | 2005-04-14 | — | — | US | disclosed |
| EP-1516869-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2005-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098505-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Thio-Substituted Arylmethanesulfinyl Derivatives by Asymmetric Oxidation | SULT1A1, TST, SULT2A1 | POLB 834/4885POLA1 544/4885CA12 2263/4885 |
| US-20120123161-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CYP2F1, SULT1A1, SULT2A1 | POLB 305/4885POLA1 153/4885CA12 2706/4885 |
| US-20130066111-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CYP2F1, SULT1A1, SULT2A1 | POLB 305/4885POLA1 153/4885CA12 2706/4885 |
| US-20050222257-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CYP2F1, SULT1A1, SULT2A1 | POLB 305/4885POLA1 153/4885CA12 2706/4885 |
| US-20060205706-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | SULT1A1, TST, SULT2A1 | POLB 834/4885POLA1 544/4885CA12 2263/4885 |
| US-20050080256-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | MAOA, CYP2F1, MAOB | POLB 219/4885POLA1 167/4885CA12 2545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.