Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALPI | P09923 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1200431 | 0.87 | PTPN1 (0.45) | POLBGAAALOX5PTPN1CYP19A1 | |
| SCHEMBL11120384 | 0.83 | MAOA (0.34) | KDM4EPOLBMAPTALDH1A1 | |
| SCHEMBL11121382 | 0.83 | CDK1 (0.47) | GAAMAPTCYP3A4MAPK1 | |
| SCHEMBL664145 | 0.83 | ALOX5 (0.39) | KDM4EPOLBGAAMAPTRECQL | |
| SCHEMBL11119917 | 0.81 | LMNA (0.40) | POLBMAPTRECQLCYP19A1CYP1A1 | |
| SCHEMBL7045176 | 0.81 | ESR1 (0.34) | GAAMAPTRECQLESR1ESR2 | |
| SCHEMBL10606553 | 0.78 | AR (0.35) | POLBMAPTCYP3A4 | |
| SCHEMBL10607710 | 0.74 | KDM4E (0.45) | KDM4EPOLBALPIGAAMAPT | |
| SCHEMBL8249167 | 0.72 | KDM4E (0.54) | KDM4EPOLBALPIGAAMAPT | |
| SCHEMBL2781922 | 0.72 | KDM4E (0.54) | KDM4EPOLBALPIGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122053-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH A FLAVANONE SKELETON AND PROCESS FOR THE PREPARATION OF SAID COMPOUNDS | INVERNI DELLA BEFFA S.P.A. (IT) | 1989-10-04 | — | — | EP | claimed |
| US-4636569-A | Pharmaceutical compositions containing compounds with a flavanone skeleton, process for the preparation of the said compound and novel compounds obtained | INVERNI DELLA BEFFA S.P.A. (IT) | 1987-01-13 | — | — | US | claimed |
| EP-0122053-A2 | Pharmaceutical compositions containing compounds with a flavanone skeleton and process for the preparation of said compounds | INVERNI DELLA BEFFA S.P.A. (IT) | 1984-10-17 | — | — | EP | claimed |
| EP-2120924-B1 | AN ANTI-DIABETIC EXTRACT OF HONEYBUSH | ZADEC APS (DK) | 2016-03-09 | — | — | EP | disclosed |
| US-20120251643-A1 | ANTI-DIABETIC EXTRACT OF HONEYBUSH | ZADEC APS (DK) | 2012-10-04 | — | — | US | disclosed |
| US-20110045108-A1 | ANTI-DIABETIC EXTRACT OF HONEYBUSH | ZADEC APS (DK) | 2011-02-24 | — | — | US | disclosed |
| EP-2120924-A2 | AN ANTI-DIABETIC EXTRACT OF HONEYBUSH | Zadec APS (DK) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008110552-A9 | AN ANTI-DIABETIC EXTRACT OF HONEYBUSH | ZADEC APS (DK) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008110552-A2 | AN ANTI-DIABETIC EXTRACT OF HONEYBUSH | ZADEC APS (DK) | 2008-09-18 | — | — | WO | disclosed |
| US-20040038914-A1 | Flavone/ flavanone derivatives for the systemic treatment and prophlaxis of uv-induced dermatoses | KRUTMANN JEAN (DE) | 2004-02-26 | — | — | US | disclosed |
| EP-0122053-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH A FLAVANONE SKELETON AND PROCESS FOR THE PREPARATION OF SAID COMPOUNDS | INVERNI DELLA BEFFA S.P.A. (IT) | 1989-10-04 | — | — | EP | disclosed |
| US-4636569-A | Pharmaceutical compositions containing compounds with a flavanone skeleton, process for the preparation of the said compound and novel compounds obtained | INVERNI DELLA BEFFA S.P.A. (IT) | 1987-01-13 | — | — | US | disclosed |
| EP-0122053-A2 | Pharmaceutical compositions containing compounds with a flavanone skeleton and process for the preparation of said compounds | INVERNI DELLA BEFFA S.P.A. (IT) | 1984-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045108-A1 | ANTI-DIABETIC EXTRACT OF HONEYBUSH | IAPP, DPP4, DPP3 | KDM4E 1708/4885POLB 2892/4885ALPI 502/4885 |
| US-20120251643-A1 | ANTI-DIABETIC EXTRACT OF HONEYBUSH | IAPP, DPP4, DPP3 | KDM4E 1708/4885POLB 2892/4885ALPI 502/4885 |
| US-20040038914-A1 | Flavone/ flavanone derivatives for the systemic treatment and prophlaxis of uv-induced dermatoses | COLGALT1, PNN, F2 | KDM4E 899/4885POLB 189/4885ALPI 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.