Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 9/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | NMT2 | O60551 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035292 | 0.96 | FURIN (0.52) | FURINSIRT6SIRT1SIRT5SIRT2 | |
| SCHEMBL30064000 | 0.88 | FOLH1 (0.49) | FURINSIRT6SIRT1SIRT5SIRT2 | |
| SCHEMBL12035287 | 0.88 | SIRT6 (0.44) | FURINSIRT6SIRT1SIRT5SIRT2 | |
| SCHEMBL17424368 | 0.87 | SIRT6 (0.49) | FURINSIRT6SIRT1SIRT5SIRT2 | |
| SCHEMBL22109057 | 0.87 | FURIN (0.50) | FURINSIRT6SIRT1NMT2NMT1 | |
| SCHEMBL22109415 | 0.87 | FURIN (0.50) | FURINSIRT6SIRT1NMT2NMT1 | |
| SCHEMBL22108983 | 0.87 | FURIN (0.50) | FURINSIRT6SIRT1NMT2NMT1 | |
| SCHEMBL22108975 | 0.87 | FURIN (0.50) | FURINSIRT6SIRT1NMT2NMT1 | |
| SCHEMBL17787396 | 0.85 | NMT2 (0.52) | FURINSIRT6SIRT1SIRT5SIRT2 | |
| SCHEMBL12035295 | 0.85 | SIRT5 (0.46) | FURINSIRT6SIRT1SIRT5SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233086-B2 | Inhibition of WDR5 interaction with its binding partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233086-B2 | Inhibition of WDR5 interaction with its binding partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-12 | — | — | US | disclosed |
| US-20110312997-A1 | Inhibition of WDR5 Interaction with Its Binding Partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2011-12-22 | — | — | US | disclosed |
| US-20110312997-A1 | Inhibition of WDR5 Interaction with Its Binding Partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312997-A1 | Inhibition of WDR5 Interaction with Its Binding Partners | WDR5, WDR77, WDR1 | FURIN 3050/4885SIRT6 2185/4885SIRT1 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.