SCHEMBL12046

SCHEMBL12046

FC1(F)Oc2ccc(Br)cc2O1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.50
CTNNB1 P35222 3/20 0.41
WNT3A P56704 3/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
BLM P54132 1/20 0.41
NOTUM Q6P988 1/20 0.40
PIK3CA P42336 1/20 0.40
PIK3CG P48736 1/20 0.40
KIF11 P52732 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
HDAC4 P56524 1/20 0.39
GPR3 P46089 1/20 0.38
CFTR P13569 1/20 0.36
SMYD3 Q9H7B4 1/20 0.36
HTR2C P28335 1/20 0.34
MRGPRX4 Q96LA9 1/20 0.34
GPR183 P32249 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL316417 0.86 AHR (0.50) AHRCTNNB1WNT3ALMNAMAPT
SCHEMBL31085202 0.86 AHR (0.50) AHRCTNNB1WNT3ALMNAMAPT
SCHEMBL1751144 0.81 GPR3 (0.35) AHRCTNNB1WNT3ANOTUMPIK3CA
SCHEMBL9349990 0.78 AHR (0.42) AHRLMNAMAPTHTTBLM
SCHEMBL25446352 0.77 AHR (0.50) AHRLMNAMAPTHTTBLM
SCHEMBL6601303 0.77 AHR (0.50) AHRLMNAMAPTHTTBLM
SCHEMBL361525 0.77 TSHR (0.56) AHRLMNAMAPTHTTBLM
SCHEMBL1752066 0.75 AHR (0.48) AHRCTNNB1WNT3ANOTUMPIK3CA
SCHEMBL10431415 0.74 GPR55 (0.46) CTNNB1WNT3ANOTUMPIK3CAPIK3CG
SCHEMBL2537768 0.74 CYP19A1 (0.43) CTNNB1WNT3AHTTNOTUMPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1374 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7524976-B2 Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives LANXESS DEUTSCHLAND GMBH (DE) 2009-04-28 US claimed
EP-1595876-B1 Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid SALTIGO GMBH (DE) 2007-12-12 EP claimed
US-20050277692-A1 Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives LANXESS DEUTSCHLAND GMBH (DE) 2005-12-15 US claimed
EP-4743453-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION Pretzel Therapeutics, Inc. (US) 2026-05-20 EP disclosed
EP-4721737-A1 USE OF PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND HAVING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE FOR TREATING ANEMIA-RELATED DISEASES Scinnohub Pharmaceutical Co., Ltd. (CN) 2026-04-08 EP disclosed
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 EP disclosed
EP-4218754-B1 VANZACAFTOR FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS VERTEX PHARMA (US) 2026-03-25 EP disclosed
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
EP-4694889-A1 COMPOUNDS AND METHODS FOR TREATING PROTEIN AGGREGATION DISEASES Acelot, Inc. (US) 2026-02-18 EP disclosed
US-20260035381-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF SUMITOMO PHARMA AMERICA, INC. (US) 2026-02-05 US disclosed
EP-4678632-A1 METHOD FOR PRODUCING ARYL COMPOUND CONTAINING TRITYLSULFANYL GROUP AGC Inc. (JP) 2026-01-14 EP disclosed
US-5194628-A Reacting metallo-difluorobenzodioxole with unsaturated nitrile and then with sulfonylmethyl isocyanide CIBA-GEIGY CORPORATION (US) 1993-03-16 US disclosed
US-4895871-A Benzoheterocyclyl ketone hydrazone insecticides FMC CORPORATION (US) 1990-01-23 US disclosed
EP-0333658-A2 Process for the preparation of substituted difluorbenzo-1,3-dioxoles CIBA-GEIGY AG (CH) 1989-09-20 EP disclosed
US-4194899-A HERBICIDES, FUNGICIDES, PLANT GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1980-03-25 US disclosed
US-4110099-A INHIBITOR FOR INTERNODEL GROWTH OF PLANTS ELI LILLY AND COMPANY (US) 1978-08-29 US disclosed
US-RE29367-E HERBICIDES, FUNGICIDES, 5-PYRIMIDINYL ELI LILLY AND COMPANY (US) 1977-08-23 US disclosed
US-4043791-A Method of regulating the growth of aquatic weeds with pyridine derivatives ELI LILLY AND COMPANY (US) 1977-08-23 US disclosed
US-4002628-A HERBICIDES, PLANT FUNGICIDES, PLANT GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1977-01-11 US disclosed
US-3967949-A Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents ELI LILLY AND COMPANY (US) 1976-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035381-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF ADH1C, HTR6, CNR1 AHR 140/4885CTNNB1 2076/4885WNT3A 3676/4885
US-20050277692-A1 Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives BROX, DDT, DAO AHR 678/4885CTNNB1 4528/4885WNT3A 4302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.