SCHEMBL120909

SCHEMBL120909

CC[n+]1ccccc1Br.F[B-](F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.43
KDM4E B2RXH2 1/20 0.36
SMN1; SMN2 Q16637 4/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
HTT P42858 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
STAT3 P40763 1/20 0.34
KMT2A Q03164 1/20 0.34
LMNA P02545 2/20 0.34
POLB P06746 1/20 0.33
BCL2 P10415 1/20 0.32
HPGD P15428 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29387158 1.00 HDAC8 (0.43) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL30054627 0.98 HDAC8 (0.42) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL1325535 0.92
SCHEMBL29399791 0.92
SCHEMBL23581841 0.90 HDAC8 (0.36) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
Hydrochloric Acid SCHEMBL1678456 0.90 HDAC8 (0.48) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL5403801 0.85 HDAC8 (0.41) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL29475405 0.84 HDAC8 (0.43) HDAC8KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL28530462 0.83 MEN1 (0.32) HDAC8KDM4EMEN1ALDH1A1KMT2A
SCHEMBL3455039 0.82 HDAC8 (0.38) HDAC8KDM4ESMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 836 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-12508321-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-12-30 US claimed
US-12496351-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-12-16 US claimed
US-20250162992-A1 METHOD FOR PRODUCING AMIDE COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-05-22 US claimed
CN-119838022-A Amatoxin conjugates containing branched linkers 杭州多禧生物科技有限公司 2025-04-18 CN claimed
EP-3774786-B1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE BAYER AG (DE) 2024-12-25 EP claimed
CN-118557747-A Conjugates of cell binding molecules and camptothecin analogs 杭州多禧生物科技有限公司 2024-08-30 CN claimed
US-11779663-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-10-10 US claimed
CN-111094281-B Chemical process for preparing monolactam antibiotics and intermediates thereof 诺华股份有限公司 2023-08-29 CN claimed
US-20230241241-A1 CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-08-03 US claimed
WO-2019026004-A2 CHEMICAL PROCESS FOR MANUFACTURING MONOBACTAM ANTIBIOTIC AND INTERMEDIATES THEREOF NOVARTIS AG (CH) 2019-02-07 WO claimed
EP-3411074-A2 SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF Suzhou M-conj Biotech Co., Ltd. (CN) 2018-12-12 EP claimed
WO-2018185526-A1 CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE HANGZHOU DAC BIOTECH CO., LTD (CN) 2018-10-11 WO claimed
EP-3317246-A2 SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE Suzhou M-conj Biotech Co., Ltd. (CN) 2018-05-09 EP claimed
US-9839687-B2 Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule SUZHOU M-CONJ BIOTECH CO., LTD. (CN) 2017-12-12 US claimed
US-20150322155-A1 ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE Sushou M-conj Biotech Co., Ltd (CN) 2015-11-12 US claimed
EP-1897901-B1 BIODEGRADABLE POLYMER, PRODUCTION METHOD THEREOF, MOLDED PRODUCT THEREOF, AND USE THEREOF MITSUI CHEMICALS INC (JP) 2015-03-11 EP claimed
US-20090142982-A1 Biodegradable Polymer, Production Method Thereof, Molded Product Thereof, and Use Thereof MITSUI CHEMICALS INC. (JP) 2009-06-04 US claimed
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates FRUTAROM LTD. (IL) 2008-09-11 US claimed
EP-1897901-A1 BIODEGRADABLE POLYMER, PRODUCTION METHOD THEREOF, MOLDED PRODUCT THEREOF, AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2008-03-12 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12508321-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers CD4, CD2, B2M HDAC8 2824/4885KDM4E 1062/4885SMN1; SMN2 4564/4885
US-20250162992-A1 METHOD FOR PRODUCING AMIDE COMPOUND NAAA, NCAPH, NCAPD2 HDAC8 130/4885KDM4E 2937/4885SMN1; SMN2 3048/4885
US-12496351-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers CD2BP2, DCLRE1A, EPCAM HDAC8 739/4885KDM4E 3062/4885SMN1; SMN2 4501/4885
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates VIP, PTMS, SSTR4 HDAC8 3690/4885KDM4E 4496/4885SMN1; SMN2 2722/4885
US-20150322155-A1 ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE DCLRE1A, AADAC, UACA HDAC8 576/4885KDM4E 3428/4885SMN1; SMN2 4698/4885
US-11779663-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof SLC25A1, GCDH, FH HDAC8 868/4885KDM4E 2368/4885SMN1; SMN2 3078/4885
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS DCLRE1A, CCR3, CCR8 HDAC8 293/4885KDM4E 4218/4885SMN1; SMN2 4051/4885
US-20230241241-A1 CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS CD4, DCLRE1A, TOP1 HDAC8 4284/4885KDM4E 4137/4885SMN1; SMN2 4335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.