SCHEMBL12100694

SCHEMBL12100694

CNc1c(-c2cccc(-c3ccccc3)c2)ccnc1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP4K4 O95819 4/20 0.41
▸ MAOA P21397 1/20 0.38
▸ MAP3K8 P41279 2/20 0.38
▸ PIK3CA P42336 2/20 0.37
▸ PIK3CD O00329 1/20 0.37
▸ PIK3CB P42338 1/20 0.37
▸ PIK3CG P48736 1/20 0.37
▸ PRKDC P78527 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ MAP2K1 Q02750 1/20 0.37
▸ ALK Q9UM73 1/20 0.37
▸ ASIC3 Q9UHC3 1/20 0.37
▸ GSK3B P49841 1/20 0.36
▸ PLAU P00749 1/20 0.36
▸ SYK P43405 2/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ PIM3 Q86V86 1/20 0.35
▸ TDO2 P48775 1/20 0.35
▸ ADORA1 P30542 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12100759 0.79 MAP4K4 (0.46) MAP4K4MAOAMAP3K8PIK3CAPIK3CD
SCHEMBL18188070 0.74 MAP4K4 (0.71) MAP4K4MAOAMAP3K8PIK3CAPIK3CD
SCHEMBL2480308 0.70 FDPS (0.53) PIK3CAPLAU
SCHEMBL15865503 0.68 NOS3 (0.54) MAP4K4MAP2K1ALKASIC3GSK3B
SCHEMBL17125578 0.67 PIK3CA (0.49) MAP4K4PIK3CAPIK3CDMAP2K1ALK
SCHEMBL14544396 0.67 NOS2 (0.41) PLAUADORA1
SCHEMBL19787487 0.66 TDO2 (0.44) MAPK1TDO2
SCHEMBL3789741 0.66 ALDH1A1 (0.56) MAP4K4PIK3CAMAPK1BRD4TDO2
SCHEMBL19991864 0.66 PIK3CA (0.59) PIK3CAMAPK1
SCHEMBL1165179 0.65 GSK3B (0.47) MAP4K4MAP2K1ALKASIC3GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11600791-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-03-07 — — US disclosed
EP-3936512-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2022-01-12 — — EP disclosed
EP-3424935-B1 IMIDAZOPYRAZINYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORP (US) 2021-08-11 — — EP disclosed
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-02-18 — — US disclosed
US-10873038-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-12-22 — — US disclosed
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-04-11 — — US disclosed
EP-3424935-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2019-01-09 — — EP disclosed
EP-2683728-B1 IRIDIUM COMPLEXES WITH 3-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE, 3-PHENYL-3H-IMIDAZO[4,5-b]PYRAZINE AND 1-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE CARBENE LIGANDS USED AS PHOSPHORESCENT EMITTERS IN ORGANIC LIGHT EMITTING DEVICES UNIVERSAL DISPLAY CORP (US) 2018-09-05 — — EP disclosed
US-9972793-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-05-15 — — US disclosed
US-20150021590-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-01-22 — — US disclosed
US-8883322-B2 Pyridyl carbene phosphorescent emitters UNIVERSAL DISPLAY CORPORATION (US) 2014-11-11 — — US disclosed
EP-2683728-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2014-01-15 — — EP disclosed
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — US disclosed
WO-2012121936-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885
US-10873038-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS PAICS, PIR, NUDC MAP4K4 2758/4885MAOA 3820/4885MAP3K8 2728/4885
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885
US-11600791-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 MAP4K4 2876/4885MAOA 2417/4885MAP3K8 3131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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