Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112567 | 0.91 | TSHR (0.46) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL12111241 | 0.88 | MRGPRX4 (0.48) | TSHRNPC1RAB9AMAPTLMNA | |
| SCHEMBL30149961 | 0.88 | KDM4E (0.57) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL30149970 | 0.88 | KDM4E (0.57) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL12848495 | 0.80 | RAB9A (0.70) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL12848935 | 0.80 | ALDH1A3 (0.58) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL30149965 | 0.79 | PDE3B (0.66) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL12111237 | 0.79 | PPARD (0.45) | — | |
| SCHEMBL12848890 | 0.79 | KDM4E (0.50) | TSHRNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL30149966 | 0.79 | RAB9A (0.60) | TSHRNPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329739-B2 | Phenylimidazole compounds | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110275823-A1 | PHENYLIMIDAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275823-A1 | PHENYLIMIDAZOLE COMPOUNDS | GPR119, PNLIP, LPL | TSHR 294/4885NPC1 80/4885RAB9A 3868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.