Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.63 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 4/20 | 0.53 |
| ▸ | RXRB | P28702 | 4/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | ADH5 | P11766 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14791856 | 0.87 | AKR1C3 (0.49) | AKR1C3AKR1C2SRD5A2S1PR1 | |
| SCHEMBL12141744 | 0.86 | NOTUM (0.49) | AKR1C3AKR1C2SRD5A2S1PR1 | |
| SCHEMBL12142108 | 0.85 | PLK1 (0.56) | AKR1C3AKR1C2SRD5A2S1PR1 | |
| SCHEMBL12141580 | 0.83 | KIF11 (0.53) | AKR1C3AKR1C2RXRARXRBRXRG | |
| SCHEMBL23302210 | 0.83 | ADH5 (0.63) | AKR1C3AKR1C2RXRARXRBSRD5A2 | |
| Hydrochloric Acid SCHEMBL28670680 | 0.82 | ADH5 (0.61) | AKR1C3AKR1C2RXRARXRBSRD5A2 | |
| SCHEMBL7368161 | 0.82 | RORC (0.48) | AKR1C3AKR1C2ALDH1A1NPC1RAB9A | |
| SCHEMBL16255738 | 0.81 | AKR1C3 (0.60) | AKR1C3AKR1C2ALDH1A1RXRARXRB | |
| SCHEMBL31236747 | 0.80 | RXRA (0.58) | AKR1C3AKR1C2RXRARXRBSRD5A2 | |
| SCHEMBL12141581 | 0.79 | CHKA (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394818-B2 | Soluble mTOR complexes and modulators thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20110288091-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288091-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | MTOR, RICTOR, RPTOR | AKR1C3 2849/4885AKR1C2 3156/4885ALDH1A1 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.