SCHEMBL12150587

SCHEMBL12150587

CCOC(=O)/C=C\[C@H]1COC(C)(C)O1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.45
TDP1 Q9NUW8 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
NPSR1 Q6W5P4 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.34
MAPT P10636 1/20 0.34
ALDH1A1 P00352 2/20 0.34
CA2 P00918 2/20 0.33
LMNA P02545 2/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
TTR P02766 1/20 0.31
DPP4 P27487 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3988831 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL4426142 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL3988833 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL4425298 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL1243883 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL9914107 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL3988829 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL4422593 1.00 L3MBTL1 (0.45) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL15355842 0.85 L3MBTL1 (0.43) L3MBTL1TDP1HCAR2NPSR1CTDSP1
SCHEMBL9812980 0.84 MAPT (0.38) L3MBTL1MAPTCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4001283-A1 SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION F. Hoffmann-La Roche AG (CH) 2022-05-25 EP disclosed
US-20190077797-A1 PROCESSES FOR PREPARING 2-DIHALO RIBOLACTONES EMORY UNIVERSITY 2019-03-14 US disclosed
US-10040815-B2 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection HOFFMANN-LA ROCHE INC. (US) 2018-08-07 US disclosed
US-20160326209-A1 NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2, 7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION HOFFMANN-LA ROCHE INC. (US) 2016-11-10 US disclosed
US-20160326209-A1 NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2, 7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION HOFFMANN-LA ROCHE INC. (US) 2016-11-10 US disclosed
US-9441008-B2 3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection HOFFMANN-LA ROCHE INC. (US) 2016-09-13 US disclosed
US-9441008-B2 3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection HOFFMANN-LA ROCHE INC. (US) 2016-09-13 US disclosed
US-9139604-B2 Antiviral phosphonate analogs GILEAD SCIENCES, INC. (US) 2015-09-22 US disclosed
US-9139604-B2 Antiviral phosphonate analogs GILEAD SCIENCES, INC. (US) 2015-09-22 US disclosed
US-20150025039-A1 ANTIVIRAL PHOSPHONATE ANALOGS GILEAD SCIENCES, INC. 2015-01-22 US disclosed
US-8022083-B2 Antiviral phosphonate analogs GILEAD SCIENCES, INC. (US) 2011-09-20 US disclosed
US-20110071101-A1 Nucleoside Phosphonate Analogs BOOJAMRA CONSTANTINE G 2011-03-24 US disclosed
US-20110071101-A1 Nucleoside Phosphonate Analogs BOOJAMRA CONSTANTINE G 2011-03-24 US disclosed
US-20100197939-A1 PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2010-08-05 US disclosed
US-20100197939-A1 PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2010-08-05 US disclosed
US-20100135977-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-06-03 US disclosed
US-20090275535-A1 ANTIVIRAL PHOSPHONATE ANALOGS GILEAD SCIENCES, INC. 2009-11-05 US disclosed
US-20090275535-A1 ANTIVIRAL PHOSPHONATE ANALOGS GILEAD SCIENCES, INC. 2009-11-05 US disclosed
US-7429565-B2 Antiviral phosphonate analogs GILEAD SCIENCES, INC. (US) 2008-09-30 US disclosed
US-7429565-B2 Antiviral phosphonate analogs GILEAD SCIENCES, INC. (US) 2008-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025039-A1 ANTIVIRAL PHOSPHONATE ANALOGS TYMP, ITPA, PNP L3MBTL1 2434/4885TDP1 976/4885HCAR2 4772/4885
US-20190077797-A1 PROCESSES FOR PREPARING 2-DIHALO RIBOLACTONES DERA, DPYD, DUS2 L3MBTL1 2700/4885TDP1 666/4885HCAR2 2358/4885
US-20110071101-A1 Nucleoside Phosphonate Analogs TYMP, PNP, NUDT1 L3MBTL1 3332/4885TDP1 340/4885HCAR2 3959/4885
US-20090275535-A1 ANTIVIRAL PHOSPHONATE ANALOGS TYMP, ITPA, PNP L3MBTL1 2434/4885TDP1 976/4885HCAR2 4772/4885
US-20100135977-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES CYP27A1, HSD17B13, GPR119 L3MBTL1 2908/4885TDP1 3257/4885HCAR2 567/4885
US-20100197939-A1 PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN GABRE, CYP2D6, GABRG2 L3MBTL1 4880/4885TDP1 3872/4885HCAR2 796/4885
US-20160326209-A1 NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2, 7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION TYMP, ZC3HAV1, TPMT L3MBTL1 2003/4885TDP1 309/4885HCAR2 2273/4885
US-10040815-B2 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection TPMT, DPYD, TYMP L3MBTL1 1367/4885TDP1 429/4885HCAR2 2000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.