Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GPR27 | Q9NS67 | 7/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12189656 | 0.87 | GPR27 (0.50) | MAPTMEN1KMT2ACYP2C19GPR27 | |
| SCHEMBL12189480 | 0.85 | ALDH1A1 (0.67) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16426276 | 0.82 | TMPRSS4 (0.64) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL12189469 | 0.82 | GRIK1 (0.67) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL12189486 | 0.81 | GPR27 (0.59) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL12189613 | 0.80 | SERPINE1 (0.65) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL12189680 | 0.79 | TMPRSS4 (0.56) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL3787204 | 0.79 | TMPRSS4 (0.76) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL16167997 | 0.77 | P2RX1 (0.55) | TMPRSS4MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL7820643 | 0.76 | ALDH1A1 (0.76) | TMPRSS4MAPTMEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859620-B2 | Phthalanilate compounds and methods of use | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | University of Nortre Dame du Lac | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | TMPRSS4 2260/4885MAPT 2792/4885MEN1 2365/4885 |
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | TMPRSS4 2260/4885MAPT 2792/4885MEN1 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.