Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 3/20 | 0.55 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.47 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16167968 | 0.85 | SORT1 (0.55) | P2RX1MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL12189469 | 0.82 | GRIK1 (0.67) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL16426276 | 0.82 | TMPRSS4 (0.64) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL18132546 | 0.80 | TMPRSS4 (0.73) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL12189613 | 0.80 | SERPINE1 (0.65) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL16167971 | 0.80 | ALDH1A1 (0.73) | MEN1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL12189680 | 0.79 | TMPRSS4 (0.56) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL12189486 | 0.78 | GPR27 (0.59) | TMPRSS4MEN1MAPTCYP2C19KMT2A | |
| SCHEMBL3787204 | 0.78 | TMPRSS4 (0.76) | P2RX1TMPRSS4GRIK1MEN1MAPT | |
| SCHEMBL12189657 | 0.77 | TMPRSS4 (0.53) | P2RX1TMPRSS4GRIK1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859620-B2 | Phthalanilate compounds and methods of use | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | P2RX1 626/4885TMPRSS4 2260/4885GRIK1 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.