SCHEMBL12190854

SCHEMBL12190854

O=S1(=O)c2ccccc2N(c2ccc(-c3ccc(N4c5ccccc5S(=O)(=O)c5ccccc54)cc3)cc2)c2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.46
FAAH O00519 1/20 0.42
MGLL Q99685 1/20 0.42
TP53 P04637 2/20 0.42
GPR3 P46089 1/20 0.41
LMNA P02545 5/20 0.41
MAPT P10636 2/20 0.41
THRB P10828 1/20 0.41
POLB P06746 1/20 0.41
PDE6D O43924 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NOX1 Q9Y5S8 1/20 0.38
HDAC1 Q13547 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
MAOA P21397 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12190900 0.94 RXFP1 (0.50) RXFP1TP53GPR3LMNAMAPT
SCHEMBL2498455 0.88 RXFP1 (0.53) RXFP1MGLLTP53GPR3LMNA
SCHEMBL20391572 0.85 RXFP1 (0.43) RXFP1FAAHMGLLTP53GPR3
SCHEMBL20275927 0.85 LMNA (0.58) RXFP1MGLLTP53GPR3LMNA
SCHEMBL2497311 0.85 RXFP1 (0.43) RXFP1MGLLTP53GPR3LMNA
SCHEMBL18267499 0.84 BRCA1 (0.42) GPR3LMNAMAPTTHRBPDE6D
SCHEMBL20383523 0.84 BRCA1 (0.48) MEN1KMT2AMAOA
SCHEMBL12190855 0.83 RXFP1 (0.48) RXFP1TP53GPR3LMNAMAPT
SCHEMBL12349299 0.83 RXFP1 (0.42) RXFP1TP53GPR3LMNAMAPT
SCHEMBL17955145 0.83 RXFP1 (0.42) RXFP1TP53GPR3LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817806-B1 PHENOTHAZINES-S-OXIDES AND S,S-DIOXIDES AS hole and excitonblockers for OLEDs BASF SE (DE) 2014-07-30 EP disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds PPOX, SMOX, SORD RXFP1 4687/4885FAAH 3754/4885MGLL 2146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.