SCHEMBL12190855

SCHEMBL12190855

O=S1(=O)c2ccccc2N(c2cc(N3c4ccccc4S(=O)(=O)c4ccccc43)cc(N3c4ccccc4S(=O)(=O)c4ccccc43)c2)c2ccccc21

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.48
TP53 P04637 3/20 0.44
GPR3 P46089 1/20 0.44
LMNA P02545 4/20 0.44
MAPT P10636 2/20 0.44
THRB P10828 1/20 0.43
POLB P06746 1/20 0.43
MAOA P21397 1/20 0.41
HTR1A P08908 1/20 0.41
HTR2A P28223 1/20 0.41
HTR7 P34969 1/20 0.41
HTR6 P50406 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NOX1 Q9Y5S8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12190905 0.92 RXFP1 (0.46) RXFP1TP53GPR3LMNAMAPT
SCHEMBL12190900 0.89 RXFP1 (0.50) RXFP1TP53GPR3LMNAMAPT
SCHEMBL11910206 0.88 HPGD (0.45) RXFP1TP53GPR3LMNAMAPT
SCHEMBL2498455 0.87 RXFP1 (0.53) RXFP1TP53GPR3LMNAMAPT
SCHEMBL2499737 0.87 LMNA (0.45) RXFP1TP53GPR3LMNAMAPT
SCHEMBL12349314 0.85 RXFP1 (0.41) RXFP1TP53GPR3LMNAMAPT
SCHEMBL23434886 0.84 RXFP1 (0.43) RXFP1TP53GPR3LMNAMAPT
SCHEMBL12190854 0.83 RXFP1 (0.46) RXFP1TP53GPR3LMNAMAPT
SCHEMBL21666686 0.83 RXFP1 (0.46) RXFP1TP53GPR3LMNAMAPT
SCHEMBL2497311 0.80 RXFP1 (0.43) RXFP1TP53GPR3LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817806-B1 PHENOTHAZINES-S-OXIDES AND S,S-DIOXIDES AS hole and excitonblockers for OLEDs BASF SE (DE) 2014-07-30 EP disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds PPOX, SMOX, SORD RXFP1 4687/4885TP53 3350/4885GPR3 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.