Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18843733 | 0.87 | AOC3 (0.37) | DRD2DRD1ALDH1A1POLBAOC3 | |
| SCHEMBL17429259 | 0.86 | MTNR1B (0.41) | DRD2DRD1CA1CA2CA7 | |
| SCHEMBL12223409 | 0.84 | KDM4E (0.44) | DRD2DRD1ALDH1A1POLBHTR7 | |
| SCHEMBL20040527 | 0.81 | DRD2 (0.37) | DRD2DRD1ALDH1A1POLBAOC3 | |
| SCHEMBL14136635 | 0.80 | AOC3 (0.52) | DRD2DRD1ALDH1A1POLBADRA1D | |
| SCHEMBL14125005 | 0.80 | DRD2 (0.40) | DRD2DRD1ALDH1A1POLBADRA1D | |
| SCHEMBL16366159 | 0.75 | DRD2 (0.42) | DRD2DRD1POLBADRA1DADRA1A | |
| SCHEMBL12439969 | 0.74 | DRD2 (0.38) | DRD2DRD1ALDH1A1POLBTSHR | |
| SCHEMBL17431881 | 0.73 | DRD2 (0.42) | DRD2DRD1AOC3TSHRKMT2A | |
| SCHEMBL14950291 | 0.72 | AOC3 (0.44) | DRD2DRD1AOC3TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771386-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771386-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | NATIONAL INSTITUTES OF HEALTH, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, U.S. GOVERNMENT | 2017-05-11 | — | — | US | disclosed |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | NATIONAL INSTITUTES OF HEALTH, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, U.S. GOVERNMENT | 2017-05-11 | — | — | US | disclosed |
| US-9446394-B2 | Z-selective ring-closing metathesis reactions | TRUSTEES OF BOSTON COLLEGE (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2015-09-03 | — | — | US | disclosed |
| US-9085595-B2 | Tungsten oxo alkylidene complexes for Z selective olefin metathesis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-21 | — | — | US | disclosed |
| US-9073801-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-07 | — | — | US | disclosed |
| US-8552242-B2 | — | — | 2013-10-08 | — | — | US | disclosed |
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | TRUSTEES OF BOSTON COLLEGE (US) | 2013-05-09 | — | — | US | disclosed |
| US-20120323000-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | TRUSTEES OF BOSTON COLLEGE (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110245477-A1 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS | TRUSTEES OF BOSTON COLLEGE (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | SOD1, ZRANB2, ZCCHC8 | DRD2 1543/4885DRD1 1502/4885CA1 3291/4885 |
| US-20110245477-A1 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS | PAICS, COASY, CYP51A1 | DRD2 3137/4885DRD1 2715/4885CA1 668/4885 |
| US-20120323000-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | DRD2 951/4885DRD1 836/4885CA1 2701/4885 |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | DRD2 951/4885DRD1 836/4885CA1 2701/4885 |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | DRD2 951/4885DRD1 836/4885CA1 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.