Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17431921 | 0.85 | DRD2 (0.40) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL20040527 | 0.84 | DRD2 (0.37) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL12197451 | 0.84 | DRD2 (0.38) | KDM4EALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL14125005 | 0.84 | DRD2 (0.40) | ALDH1A1KMT2APOLBGAARAB9A | |
| SCHEMBL14136635 | 0.84 | AOC3 (0.52) | KDM4EALDH1A1MAPTKMT2APOLB | |
| SCHEMBL18843733 | 0.79 | AOC3 (0.37) | ALDH1A1POLBGAAHTR7HTR2A | |
| SCHEMBL16366159 | 0.79 | DRD2 (0.42) | KMT2APOLBGAARAB9ADRD2 | |
| SCHEMBL1145699 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HPGDSMN1; SMN2HTR7HTR2A | |
| SCHEMBL17431881 | 0.76 | DRD2 (0.42) | MAPTKMT2AGAARAB9ADRD2 | |
| SCHEMBL25910897 | 0.76 | CHEK1 (0.40) | KMT2AGAADRD2CYP19A1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534140-B1 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS | TRUSTEES BOSTON COLLEGE (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9776179-B2 | Production of fatty olefin derivatives via olefin metathesis | PROVIVI, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9771386-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-09-26 | — | — | US | disclosed |
| EP-2721027-B1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | MASSACHUSETTS INST TECHNOLOGY (US) | 2017-05-31 | — | — | EP | disclosed |
| US-20170137365-A1 | PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS | PROVIVI, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | NATIONAL INSTITUTES OF HEALTH, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, U.S. GOVERNMENT | 2017-05-11 | — | — | US | disclosed |
| US-9446394-B2 | Z-selective ring-closing metathesis reactions | TRUSTEES OF BOSTON COLLEGE (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2015-09-03 | — | — | US | disclosed |
| US-9085595-B2 | Tungsten oxo alkylidene complexes for Z selective olefin metathesis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-21 | — | — | US | disclosed |
| US-9073801-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140330018-A1 | METATHESIS CATALYSTS AND METHODS THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-11-06 | — | — | US | disclosed |
| US-8552242-B2 | — | — | 2013-10-08 | — | — | US | disclosed |
| US-8546500-B2 | Complexes for use in metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | TRUSTEES OF BOSTON COLLEGE (US) | 2013-05-09 | — | — | US | disclosed |
| US-20120323000-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | TRUSTEES OF BOSTON COLLEGE (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110245477-A1 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS | TRUSTEES OF BOSTON COLLEGE (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | SOD1, ZRANB2, ZCCHC8 | KDM4E 4640/4885ALDH1A1 2922/4885MAPT 3265/4885 |
| US-20170137365-A1 | PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS | SREBF1, F2, SREBF2 | KDM4E 4504/4885ALDH1A1 1913/4885MAPT 4842/4885 |
| US-20110245477-A1 | EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS | PAICS, COASY, CYP51A1 | KDM4E 4435/4885ALDH1A1 701/4885MAPT 4607/4885 |
| US-20140330018-A1 | METATHESIS CATALYSTS AND METHODS THEREOF | TERT, CYP19A1, MPO | KDM4E 2110/4885ALDH1A1 109/4885MAPT 4037/4885 |
| US-20120323000-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | KDM4E 2372/4885ALDH1A1 1620/4885MAPT 3406/4885 |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | KDM4E 2372/4885ALDH1A1 1620/4885MAPT 3406/4885 |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | KDM4E 2372/4885ALDH1A1 1620/4885MAPT 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.