SCHEMBL1222893

SCHEMBL1222893

CCOC(=O)c1ccc2[nH]ccc2c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.67
HCRTR1 O43613 2/20 0.55
TAS1R3 Q7RTX0 1/20 0.54
TAS1R1 Q7RTX1 1/20 0.54
ALDH1A1 P00352 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
MAPT P10636 2/20 0.54
RAB9A P51151 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
CA12 O43570 2/20 0.53
CA1 P00915 2/20 0.53
CA2 P00918 2/20 0.53
CA7 P43166 2/20 0.53
CA9 Q16790 2/20 0.53
CA14 Q9ULX7 2/20 0.53
CTNNB1 P35222 3/20 0.52
WNT3A P56704 3/20 0.52
HPGD P15428 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31094660 1.00 MAOA (0.67) MAOAHCRTR1TAS1R3TAS1R1ALDH1A1
Hydrochloric Acid SCHEMBL28263903 0.98 MAOA (0.65) MAOAHCRTR1TAS1R3TAS1R1ALDH1A1
SCHEMBL827892 0.88 ALDH1A1 (0.58) MAOAHCRTR1TAS1R3TAS1R1ALDH1A1
SCHEMBL11612464 0.85 ESR1 (0.54) MAOATAS1R3TAS1R1SMN1; SMN2CTNNB1
SCHEMBL3708930 0.84 MAOA (0.51) MAOAHCRTR1TAS1R3TAS1R1ALDH1A1
SCHEMBL8132038 0.84 TAS1R3 (0.57) MAOATAS1R3TAS1R1ALDH1A1MAPT
SCHEMBL27835581 0.84 MAOA (0.50) MAOATAS1R3TAS1R1MAPTRAB9A
SCHEMBL27553735 0.83 NPC1 (0.55) MAOAALDH1A1MAPTRAB9AESR1
SCHEMBL4914970 0.83 MAOA (0.83) MAOAALDH1A1MEN1KMT2AMAPT
SCHEMBL6874059 0.83 MAOA (0.50) MAOATAS1R3TAS1R1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1914207-A Aza * -indoline derivatives as medicaments EXELIXIS INC (US) 2007-02-14 CN claimed
CN-1852748-A Azepine derivatives as pharmaceutical agents EXELIXIS INC (US) 2006-10-25 CN claimed
WO-1998007716-A2 HETEROAROTINOIDS-ANTICANCER AGENTS WITH RECEPTOR SPECIFICITY AND TGASE ACTIVITY THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY (US) 1998-02-26 WO claimed
US-20260069602-A1 COMPOUNDS, COMPOSITIONS, AND METHODS ACONCAGUA BIO INC (US) 2026-03-12 US disclosed
CN-119490487-A Polysubstituted tetrahydrocarbazole compound, preparation method, pharmaceutical composition and application thereof 中国科学院上海药物研究所 2025-02-21 CN disclosed
CN-118437307-A Application of amorphous carbon material and synthetic method of poly-deuterated aromatic compound 无锡绿能电合科技有限公司 2024-08-06 CN disclosed
CN-117616028-A 2, 8-dihydropyrazolo [3,4-B ] indole derivatives for the treatment of cancer 默克专利股份公司 2024-02-27 CN disclosed
CN-117337193-A combination therapy 基因泰克公司 2024-01-02 CN disclosed
CN-115515959-A Tricyclic heterocycles as TEAD binders 默克专利股份公司 2022-12-23 CN disclosed
CN-115427044-A Pyrrolopyrimidines as complement inhibitors 拜奥克里斯特制药公司 2022-12-02 CN disclosed
CN-110404073-A Treat hepatitis b virus infected method and pharmaceutical composition INSERM INSTITUT NATIONAL DE LASANTE ET DE LA RECH MEDICALE 2019-11-05 CN disclosed
WO-1997021707-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed
CN-1106811-A Piperidines and piperazines MERCK PATENG GES MIT BESCHRAEN (DE) 1995-08-16 CN disclosed
US-5242925-A PIPERAZINYLBENZODIOXANE DERIVATIVES MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-09-07 US disclosed
EP-0529462-A1 Benzodioxan derivatives MERCK PATENT GmbH (DE) 1993-03-03 EP disclosed
US-4101583-A Alpha-methylthio-alpha-(2-aminophenyl) acetaldehyde diloweralkyl acetals THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1978-07-18 US disclosed
US-4080341-A Carbazolenine and indole compounds THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1978-03-21 US disclosed
US-4067875-A Certain N-phenyl or N-pyridyl aza sulfonium salts THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1978-01-10 US disclosed
US-3992392-A Synthesis of indoles from anilines and intermediates therein THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1976-11-16 US disclosed
US-3976639-A Intermediates for indoles HOFFMANN-LA ROCHE INC. (US) 1976-08-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260069602-A1 COMPOUNDS, COMPOSITIONS, AND METHODS SCTR, SSTR1, NPY1R MAOA 3403/4885HCRTR1 46/4885TAS1R3 163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.